Browsing by Author "400c3982-3c9d-4f67-9057-b8d4a4e913ce"

Now showing items 1-11 of 11

    • Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension 
      Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function 
      Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)
      To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
    • Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles - A new family of ... 
      Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)
      A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
    • Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting ... 
      Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)
      © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
    • Dictyostelium discoideum as a surrogate host–microbe model for antivirulence screening in Pseudomonas ... 
      Bravo Toncio, Catalina; Alvárez, Javiera A.; Campos, Francisca; Ortiz Severin, Javiera; Varas, Macarena; Cabrera Paucar, Ricardo; Lagos, Carlos F.; Chávez, Francisco P. (Elsevier, 2016)
      The interest of the pharmaceutical industry in developing new antibiotics is decreasing, as established screening systems which identify compounds that kill or inhibit the growth of bacteria can no longer be used. Consequently, ...
    • Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase ... 
      Tobar, Hugo E.; Cataldo, Luis R.; González, Trinidad; Rodríguez, Ricardo; Serrano, Valentina; Arteaga, Antonio; Álvarez-Mercado, Ana; Lagos, Carlos F.; Vicuña, Lucas; Miranda, José P.; Pereira, Ana; Bravo, Carolina; Aguilera, Concepción M.; Eyheramendy, Susana; Uauy Dagach-Imbarack, Ricardo (BioMed Central Ltd., 2019)
      Background: Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme that esterifies cholesterol in high- and low-density lipoproteins (HDL and LDL). Mutations in LCAT gene causes familial LCAT deficiency, which is ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions ... 
      Lagos, Carlos F.; Araya Secchi, Raúl; Thomas, Pablo; Pérez-Acle, Tomás; Tapia, Ricardo A.; Salas, Cristian O. (2012)
      Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL ...
    • On biophysical properties and sensitivity to gap junction blockers of connexin 39 hemichannels expressed ... 
      Vargas, Anibal A.; Cisterna, Bruno A.; Saavedra-Leiva, Fujiko; Urrutia, Carolina; Cea, Luis A.; Vielma, Alex H.; Gutiérrez Maldonado, Sebastián; Martin, Alberto J.M.; Pareja-Barrueto, Claudia; Escalona, Yerko; Schmachtenberg, Oliver; Lagos, Carlos F.; Pérez-Acle, Tomás (Frontiers Research Foundation, 2017)
      © 2017 Vargas, Cisterna, Saavedra-Leiva, Urrutia, Cea, Vielma, Gutierrez-Maldonado, Martin, Pareja-Barrueto, Escalona, Schmachtenberg, Lagos, Perez-Acle and Sáez. Although connexins (Cxs) are broadly expressed by cells of ...
    • Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system 
      Ocaranza, María Paz; Michea Acevedo, Luis; Chiong Lay, Mario; Lagos, Carlos F.; Lavandero González, Sergio; Jalil Milad, Jorge (Portland Press Ltd, 2014)
      Chronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and atherogenic effects ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 
      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal; Lagos, Carlos; Rojas, Maria; Muñoz, Doris; Fardella, Carlos E. (Oxford University Press, 2018)
      BACKGROUND : Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, ...