Browsing by Author "42073c5c-11e4-42af-a689-9f44579f4a62"

Now showing items 1-6 of 6

    • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive ... 
      Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress 
      Fuentes Villalobos, Francisco; Farkas, Carlos; Riquelme Barrios, Sebastián; Armijo, Marisol E.; Soto Rifo, Ricardo; Pincheira, Roxana; Castro, Ariel F. (Elsevier B.V., 2019)
      Variation in Disrupted-in-Schizophrenia 1 (DISC1) increases the risk for neurodegenerative diseases, schizophrenia, and other mental disorders. However, the functions of DISC1 associated with the development of these ...
    • Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival 
      Campos, Tania; Ziehe, Javiera; Fuentes Villalobos, Francisco; Riquelme, Orlando; Peña, Daniela; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Morín, Violeta; Pincheira, Roxana; Castro, Ariel F. (Elsevier, 2016)
      Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
    • SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes 
      Hermosilla, Viviana; Salgado, Ginessa; Riffo, Elizabeth; Escobar, David; Hepp, Matias; Farkas, Carlos; Galindo, Mario; Morín, Violeta; García-Robles, María; Castro, Ariel; Pincheira, Roxana (Wiley, 2018-06)
      SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...
    • Sall2 transcription factor: a novel regulator of G1-S cyclins 
      Hermosilla, Viviana E.; Escobar, David E.; Hepp, Matias I.; Riffo, Elizabeth N.; Salgado, Ginessa; Morin, Violeta; Galindo, Mario A.; Castro, Ariel F.; Pincheira, Roxana (Amer Assoc. Cancer Research, 2018-05)
    • β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation 
      Pinto, Cristina; Medinas, Danilo B.; Fuentes Villalobos, Francisco; Maripillán, Jaime; Castro, Ariel F.; Martínez, Agustín D.; Osses, Nelson; Hetz Flores, Claudio; Henríquez, Juan P. (Academic Press Inc., 2019)
      Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...