Browsing by Author "45445664-35dc-4f21-8959-a4558718c141"

Now showing items 1-6 of 6

    • A new method to measure autophagy flux in the nervous system 
      Matus, Soledad; Valenzuela, Vicente; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
    • Gene Therapy Strategies to Restore ER Proteostasis in Disease 
      Valenzuela, Vicente; Jackson, Kasey L.; Sardi, Sergio P.; Hetz Flores, Claudio (Cell Press, 2018)
      © 2018 The American Society of Gene and Cell Therapy Proteostasis alterations are proposed as a transversal hallmark of several pathological conditions, including metabolic disorders, mechanical injury, cardiac malfunction, ...
    • Gene therapy to target ER stress in brain diseases 
      Valenzuela, Vicente; Martínez, Gabriela; Durán Aniotz, Claudia; Hetz Flores, Claudio (Elsevier B.V., 2016)
      © 2016 Elsevier B.V. Gene therapy based on the use of Adeno-associated viruses (AAVs) is emerging as a safe and stable strategy to target molecular pathways involved in a variety of brain diseases. Endoplasmic reticulum ...
    • Injury to the nervous system: A look into the ER 
      Valenzuela, Vicente; Oñate, Maritza; Hetz Flores, Claudio; Court, Felipe A. (Elsevier B.V., 2016)
      © 2016 Elsevier B.V.Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 
      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Unraveling the role of motoneuron autophagy in ALS 
      Valenzuela, Vicente; Nassif, Melissa; Hetz Flores, Claudio (Taylor and Francis Inc., 2018)
      © 2018 Informa UK Limited, trading as Taylor & Francis Group. In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. ...