Browsing by Author "4899ae5b-957d-46d8-bd7d-8145ac7ca196"

Now showing items 1-12 of 12

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA ... 
      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • Developmental regulation of the expression of sodium currents in Xenopus primary neurons 
      Olguín Aguilera, Patricio; Armisen Yáñez, Ricardo; Kukuljan Padilla, Manuel (SOCIEDAD BIOLGIA CHILE, 2006)
      The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, ...
    • Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation 
      Jain, J.; Moreno, J.; Andaur, R.; Armisen Yáñez, Ricardo; Morales D., Ignacio; Marcelain Cubillos, Katherine; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Soto, L. (American Institute of Physics, 2017)
      Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely ...
    • Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death 
      Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Immune DNA signature of T-cell infiltration in breast tumor exomes 
      Levy, Eric; Marty, Rachel; Gárate Calderón, Valentina; Woo, Brian; Dow, Michelle; Armisen Yáñez, Ricardo; Carter, Hannah; Harismendy, Olivier (Nature, 2016)
      Tumor infiltrating lymphocytes (TILs) have been associated with favorable prognosis in multiple tumor types. The Cancer Genome Atlas (TCGA) represents the largest collection of cancer molecular data, but lacks detailed ...
    • Increased expression of the transient receptor potential melastatin 7 channel is critically involved in ... 
      Núñez-Villena, Felipe; Becerra, Alvaro; Echeverría, Cesar; Briceño, Nicolás; Porras Espinoza, Omar; Armisen Yáñez, Ricardo; Varela, Diego; Montorfano, Ignacio; Sarmiento, Daniela; Simon, Felipe (2011)
      Aims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: ...
    • L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes 
      Hermosilla, Tamara; Moreno, Cristian; Itfinca, Mircea; Altier, Christophe; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Zamponi, Gerald W.; Varela, Diego (Taylor and Francis Inc., 2011)
      Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
    • Preliminary assessment of a targeted break-point NGS assay for ALK gene fusion detection in lung adenocarcinoma ... 
      Freire, M.; Lizana, R.; Ramos, L.; Sepúlveda, G.; Blanco, A.; Chernilo, S.; Aren, O.; Fernández, C.; Armisen Yáñez, Ricardo (Elsevier, 2018-04)
    • Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress 
      Torres, Mauricio; Castillo, Karen; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Soto, Claudio; Hetz Flores, Claudio (2010)
      Prion-related disorders (PrDs) are fatal neurodegenerative disorders characterized by progressive neuronal impairment as well as the accumulation of an abnormally folded and protease resistant form of the cellular prion ...
    • The characterization of anti-T-cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ... 
      Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen Yáñez, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramírez Tagle, Rodrigo (Springer, 2016)
      Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity ...
    • TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the ... 
      Rojas Rivera, Diego; Armisen Yáñez, Ricardo; Colombo, A.; Martínez, G.; Eguiguren, A. L.; Díaz, A.; Kiviluoto, S.; Rodríguez, D.; Patron, M.; Rizzuto, R.; Bultynck, G.; Concha Nordemann, Miguel; Sierralta, J.; Stutzin Schottlander, Andrés; Hetz Flores, Claudio (2012)
      Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we report ...
    • TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway 
      Armisen Yáñez, Ricardo; Marcelain Cubillos, Katherine; Simon, Felipe; Tapia, Julio C.; Toro, Jessica; Quest, Andrew F. G.; Stutzin Schottlander, Andrés (2011)
      Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin ...