Browsing by Author "495b7efc-047a-40e7-a9cd-419aa40053ad"

Now showing items 1-8 of 8

    • Autophagy and its impact on neurodegenerative diseases: new roles for TDP-43 and C9orf72 
      Budini, Mauricio; Buratti, Emanuele; Morselli, Eugenia; Criollo Céspedes, Alfredo (Frontiers, 2017-05-30)
      Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to maintain the normal function of the central nervous system (CNS), ...
    • Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1α 
      Budini, Mauricio; Jacob, Germaine; Jedlicki, Ana; Pérez, Carolina; Allende, Catherine C.; Allende, Jorge E. (2009)
      CK1 constitutes a protein kinase subfamily that is involved in many important physiological processes. However, there is limited knowledge about mechanisms that regulate their activity. Isoforms CK1δ and CKlε were previously ...
    • Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation 
      Ormeño, Fernando; Hormazábal, Juan; Moreno, José; Riquelme, Felipe; Ríos, Javiera; Criollo Céspedes, Alfredo; Albornoz, Amelina; Alfaro, Iván E.; Budini, Mauricio (Frontiers Media, 2020)
      TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative ...
    • Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders 
      Alfaro, Iván E.; Albornoz, Amelina; Molina, Alfredo; Moreno, José; Cordero, Karina; Criollo Céspedes, Alfredo; Budini, Mauricio (Frontiers Media, 2019)
      Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While ...
    • Hyperosmotic stress stimulates autophagy via polycystin-2 
      Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted of casein kinase 1α is associated with ... 
      Campagna, Michela; Budini, Mauricio; Arnoldi, Francesca; Desselberger, Ulrich; Allende, Jorge E.; Burrone, Oscar R. (2007)
      The rotavirus (RV) non-structural protein 5, NSP5, is encoded by the smallest of the 11 genomic segments and localizes in 'viroplasms', cytoplasmic inclusion bodies in which viral RNA replication and packaging take place. ...
    • Poly(GP) proteins: A potential pharmacodynamic marker in ALS and FTD 
      Budini, Mauricio; Criollo Céspedes, Alfredo (AME Publishing Company, 2017)
    • Polycystin-2 is required for starvation- And rapamycin-induced atrophy in myotubes 
      Kretschmar, Catalina; Peña Oyarzún, Daniel; Hernando, Cecilia; Hernández Moya, Nadia; Molina Berríos, Alfredo Enrique; Hernández-Cáceres, María Paz; Lavandero González, Sergio; Budini, Mauricio; Morselli, Eugenia; Parra, Valentina; Troncoso, Rodrigo; Criollo Céspedes, Alfredo (Frontiers Media S.A., 2019)
      Copyright © 2019 Kretschmar, Peña-Oyarzun, Hernando, Hernández-Moya, Molina-Berríos, Hernández-Cáceres, Lavandero, Budini, Morselli, Parra, Troncoso and Criollo.Muscle atrophy involves a massive catabolism of intracellular ...