Browsing by Author "52fccf3a-4e8f-4fea-8487-8a23298465a3"

Now showing items 1-4 of 4

    • Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically ... 
      Román Albasini, Luciano; Díaz Véliz, Gabriela; Olave, Felipe Antonio; Aguayo, Felipe Ignacio; García Rojo, Gonzalo; Corrales, Wladimir Antonio; Silva, Juan Pablo; Ávalos, Ana María; Rojas, Paulina S.; Aliaga, Esteban; Fiedler, Jenny Lucy (Elsevier, 2020)
      Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated protein ...
    • Chronic stress triggers expression of immediate early genes and differentially affects the expression of ... 
      Pacheco Zapata, Aníbal; Aguayo, Felipe I.; Aliaga, Esteban; Muñoz, Mauricio; García Rojo, Gonzalo; Olave, Felipe A.; Parra Fiedler, Nicolás; García Pérez, Alexandra; Tejos Bravo, Macarena; Rojas, Paulina S.; Parra, Claudio S.; Fiedler Temer, Jenny (Frontiers media SA, 2017)
      Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared ...
    • Matrix metalloproteinase 9 displays a particular time response to acute stress: variation in its levels and ... 
      Aguayo, Felipe I.; Pacheco Zapata, Aníbal; García Rojo, Gonzalo; Pizarro Bauerle, Javier; Doberti Martínez, Ana Valentina; Tejos Bravo, Macarena; García-Pérez, María A.; Rojas, Paulina S.; Fiedler Temer, Jenny (ACS Publications, 2018-05)
      A single stress exposure facilitates memory formation through neuroplastic processes that reshape excitatory synapses in the hippocampus, probably requiring changes in extracellular matrix components. We tested the hypothesis ...
    • The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic ... 
      García Rojo, Gonzalo; Fresno, Cristóbal; Vilches Peñaloza, Natalia; Díaz Véliz, Emma; Mora Gutiérrez, Sergio; Aguayo Abarca, Felipe; Pacheco Zapata, Aníbal; Parra Fiedler, Nicolás; Parra, Claudio; Rojas Domínguez, Paulina; Tejos Bravo, Macarena; Aliaga, Esteban; Fiedler Temer, Jenny (Oxford University Press, 2017-04-01)
      Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...