Browsing by Author "5931b2ad-3a48-4497-8e3d-19f9c2a0ebed"

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Artículo

Association between IRF6 variants and nonsyndromic cleft lip with or without cleft palate in Chile

Suazo Sanhueza, José; Recabarren, Andrea S.; Marín, Nicolás R.; Blanco Castillo, Rafael (Springer, 2020)

The aim of this study was to assess the association betweenIRF6single nucleotide polymorphisms and nonsyndromic cleft lip, with or without cleft palate (NSCL/P), in a Chilean population, based on a case-control sample and ...
Artículo

Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis

Blanco Castillo, Rafael; Colombo Flores, Alicia; Pardo Vargas, Rosa; Suazo Sanhueza, José Lorenzo (Elsevier, 2016)

Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting ...
Artículo

MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile

Ramírez Chau, Cristian Adolfo; Blanco Castillo, Rafael; Colombo Flores, Alicia; Pardo Vargas, Rosa; Suazo Sanhueza, José Lorenzo (Wiley Blackwell, 2016)

Objective The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C>T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or ...