Browsing by Author "5f6b8f62-0c00-42a3-bf86-8487e606682f"

Now showing items 1-5 of 5

    • An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling 
      Ibarra, Cristián; Vicencio Bustamante, José Miguel; Varas Godoy, Manuel; Jaimovich Pérez, Enrique; Rothermel, Beverly A.; Uhlén, Per; Hill, Joseph A.; Lavandero González, Sergio (Academic Press, 2014)
      © 2014 Elsevier Ltd. In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical ...
    • Ca2+/ Calmodulin dependent protein kinase II and androgen signaling pathways modulate MEF2 activity in ... 
      Durán, Javier; Lagos, Daniel; Pavez, Mario; Troncoso, Mayarling F.; Ramos, Sebastián; Barrientos Briones, Genaro; Ibarra, Cristián; Lavandero González, Sergio; Estrada Hormazábal, Manuel (Frontiers media SA, 2017)
      Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...
    • Evaluation of connective tissue diseases in patients presenting with interstitial lung disease in a referral ... 
      Wolff Cecchi, Verónica; Florenzano Valdés, Matías; Rivera, Angela; Cuellar, Carolina; Maya Arango, Juan; Salinas Fenero, Mauricio; Ibarra, Cristián; Bello, Angélica; Soto, Daniela (Wiley, 2017)
    • GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy 
      Durán, Javier; Oyarce Díaz, César; Pavez Giani, Mario; Valladares, Denisse; Basualto Alarcón, Carla; Lagos, Daniel; Barrientos Briones, Genaro; Troncoso Magñin, Mayarling; Ibarra, Cristián; Estrada Hormazábal, Manuel; Basualto Alarcón, Carla (Public Library Science, 2016-12-15)
      Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...
    • Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and ... 
      Ibarra, Cristián; Estrada Hormazábal, Manuel; Carrasco Mujica, Loreto; Chiong Lay, Mario; Liberona Leppe, José; Cárdenas, César; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Amer Biochemistry Molecular Biology, 2004-02-27)
      In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca-i(2+) levels apparent both in the nucleus ...