Now showing items 1-20 of 64

    • Ponce, Iván; Aldunate, Carmen; Valenzuela, Lucía; Sepúlveda Contreras, Sofía; Garrido, Gilda; Kemmerling Weis, Ulrike; Cabrera Vallejos, Gonzalo; Galanti Garrone, Norbel (Wiley, 2017)
      FLAP endonucleases (FEN) are involved both in DNA replication and repair by processing DNA intermediaries presenting a nucleotide flap using its phosphodiesterase activity. In spite of these important functions in DNA ...
    • Liempi Manquel, Ana; Castillo Varela, Christian; Carrillo Werner, Ileana; Muñoz Clavijo, Lorena; Droguett Ossa, Daniel; Galanti Garrone, Norbel; Maya Arango, Juan; Kemmerling Weis, Ulrike (Academic Press, 2016)
      Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends ...
    • Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Leiva, Mario; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Elsevier, 2013)
      Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
    • Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana, Myriam; Maya Arango, Juan (2008)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Kemmerling Weis, Ulrike; Muñoz Dimitrov, Pablo; Müller, Marioly; Sánchez, Gina; Aylwin Ostale, María de la Luz; Klann, Eric; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (2007)
      Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
    • Carrillo, Ileana; Castillo, Christian; Droguett, Daniel; Muñoz, Lorena; Liempi, Ana; Maya Arango, Juan; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (2016)
      Congenital Chagas’ disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi), which is able to cross the placental barrier and infect both the placenta and fetus. However, congenital transmission ...
    • Carrillo Werner, Ileana; Droguett Ossa, Daniel; Castillo Varela, Christian; Liempi Manquel, Ana; Muñoz Clavijo, Lorena; Maya Arango, Juan; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (Academic Press-Elsevier, 2016)
      Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood ...
    • Maya Arango, Juan; Orellana, Myriam; Ferreira, Jorge; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo; Morello Casté, Antonio (Society of Biology of Chile, 2010)
      There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma ...
    • Liempi, Ana; Castillo Rivas, Christian; Medina, Lisvaneth; Galanti, Norbel; Maya Arango, Juan; Parraguez Gamboa, Víctor; Kemmerling Weis, Ulrike (Elsevier, 2020)
      Trypanosoma cruzi, the causative agent of Chagas disease, and Toxoplasma gondii, which is responsible for Toxoplasmosis, are two parasites that cause significant protozoan zoonoses and consequently important economic losses ...
    • Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Apt Baruch, Werner; Zulantay Alfaro, Inés; Arnello, Marcela; Oddó, David; González, Sandra; Rodríguez Borges, Jorge; Kemmerling Weis, Ulrike; Truyens, Carine; Carlier, Yves (2013)
      Background: This study investigated the prevalence of Chagas disease (ChD) in pregnant women in Choapa Province (IV Region, Chile) and the vertical transmission of Trypanosoma cruzi. Method: ELISA and IFI IgG for ChD was ...
    • Díaz Luján, Cintia; Triquell, M.; Bolatti, E.; Moreira Espinoza, M.; Hardisson, D.; Castillo, C.; Kemmerling Weis, Ulrike; Fretes, Ricardo (W B SAUNDERS, 2015)
    • Gallardo, Marcela; Kemmerling Weis, Ulrike; Aguayo González, Francisco; Bleak, Tammy; Muñoz, Juan P.; Calaf, Gloria (Spandidos Publications, 2020)
      Breast cancer is the most prevalent type of cancer among women worldwide and it is characterized by a high morbidity. Curcumin is a naturally occurring compound derived from the rhizome of Curcuma longa and is known to ...
    • Peredo Silva, Liliana; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Pavani Costa, Mario; Maya Arango, Juan; Castro Castillo, Vicente; Madrid Rojas, Matías; Rebolledo, Solange; Kemmerling Weis, Ulrike; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2017)
      We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
    • Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; Valenzuela, Lucía; Galanti Garrone, Norbel; de los Angeles Curto, María; Schijman, Alejandro G.; Kemmerling Weis, Ulrike (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become epidemiologically relevant. The probability of congenital transmission depends on the maternal and developing fetal/newborn ...
    • López Solís, Remigio; Puente Díaz, Margarita; Morales Bozo, Irene; Kemmerling Weis, Ulrike; Rojas Díaz, Francisco Rafael (2003)
      Chronic administration of isoproterenol (IPR) results in a marked hypertrophy and in the induction of a group of putative proline-rich polypeptides in the mouse parotid glands. Some of these polypeptides (pps C-G) have ...
    • Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)
      A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
    • Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado Maldonado, Edio (Public Library Science, 2018)
      Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
    • Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado, Edio (Public Library of Science, 2018)
      © 2018 Rojas et al. Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and ...