Browsing by Author "6892e5ea-c83f-40b4-b5a5-1a67111baee8"

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    • Erratum to: Targeting hepatic glutaminase activity to ameliorate hyperglycemia (Nature Medicine, (2018), ... 
      Miller, Russell A.; Shi, Yuji; Lu, Wenyun; Pirman, David A.; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas, César; Wan, Min; Foskett, J. Kevin; Park, Junyoung O.; Zhang, Yiyi; Holland, William L.; Rabinowitz, Joshua D.; Birnbaum, Morris J. (Nature Publishing Group, 2018)
      © 2018, The Publisher. In the version of this article initially published, the “[13C2]α-ketoglutarate” label on Fig. 1g is incorrect. It should be “[13C5]α-ketoglutarate”. Additionally, in Fig. 3b, the “AAV-GFP” group is ...
    • InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer 
      Lovy, Alenka; Foskett, J. Kevin; Cárdenas, César (Taylor & Francis, 2016-06)
      Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca2+ transfer to mitochondria as an unexpected requirement for ...
    • Mitochondrial Ca2+ signals in autophagy 
      Cárdenas, César; Foskett, J. Kevin (Elsevier Ltd, 2012)
      Macroautophagy (autophagy) is a lysosomal degradation pathway that is conserved from yeast to humans that plays an important role in recycling cellular constituents in all cells. A number of protein complexes and signaling ...
    • Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria 
      Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaňa, Fabian; Bustos, Galdo; Urra, Felix; Smith, Natalia; Molgó, Jordi; Diehl, J. Alan; Ridky, Todd W.; Foskett, J. Kevin (Elsevier B.V., 2016)
      © 2016 The Authors.In the absence of low-level ER-to-mitochondrial Ca2+ transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we ...
    • Targeting hepatic glutaminase activity to ameliorate hyperglycemia 
      Miller, Russell A.; Shi, Yuji; Lu, Wenyun; Pirman, David A.; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas Matus, Julio; Wan, Min; Foskett, J. Kevin; Park, Junyoung O.; Zhang, Yiyi; Holland, William L.; Rabinowitz, Joshua D.; Birnbaum, Morris J. (Nature Publishing Group, 2018)
      Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic ...