Browsing by Author "6d2f4e64-b3b7-47e0-b560-dbfede86c47c"
Now showing items 1-20 of 36
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Israel Jacard, Yedy; Karahanian, Eduardo; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Quintanilla González, María Elena (Frontiers Media S.A., 2017)© 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
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Quintanilla González, María Elena; Perez, Elizabeth; Tampier, Lutske (2008)Treatment with γ-aminobutiric acid (GABAB) receptor agonist, ±baclofen, has been shown to reduce ethanol intake in selectively bred Sardinian alcohol-preferring rats. The general goal of the present study was to characterize ...
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Quintanilla González, María Elena; Morales, Paola; Ezquer, Fernando; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)© 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske; Valle-Prieto, Araceli; Sapag, Amalia; Israel Jacard, Yedy (FEDERATION AMER SOC EXP BIOL, 2005-06)Animals selectively bred for a desirable trait retain wanted genes but exclude genes that may counteract the expression of the former. The possible interactions between selected and excluded genes cannot be readily studied ...
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Quintanilla González, María Elena; Bustamante, Diego; Tampier de Jong, Lutske; Israel Jacard, Yedy; Herrera-Marschitz Muller, Mario (2007)Lower tissue levels of dopamine and 5-hydroxytryptamine (5-HT) have been found in the nucleus accumbens of alcohol-naïve rats selectively bred to prefer ethanol than in rats bred to avoid it. These findings have led to the ...
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Tampier, Lutske; Quintanilla González, María Elena (2009)This study examined the effect of concurrent presentation of a highly palatable saccharin solution on ethanol consumption during the acquisition or maintenance of ethanol drinking by high-alcohol-drinking (UChB) rats. Rats ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Mardones, Jorge (1995)Aminotriazole (AT), a catalase inhibitor, was administered to UChA (low ethanol consumer) and UChB (high ethanol consumer) rats. Ethanol, water, and solid food intake were measured during basic, treatment, and posttreatment ...
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Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera Meza, Mario; Quintanilla González, María Elena; Sotomayor Zárate, Ramón (Elsevier, 2018-09)Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol ...
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Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Rivera Meza, Mario; Bustamante, Diego; González Lira, Víctor; Morales, Paola; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (2011)Background: While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that the rewarding effects of alcohol ...
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Bustamante, Diego; Quintanilla González, María Elena; Tampier de Jong, Lutske; González, Víctor; Israel Jacard, Yedy; Herrera-Marschitz Muller, Mario (ELSEVIER, 2008-09-04)Several studies on the differences between ethanol-preferring versus non-preferring rat lines suggest an innate deficit in the mesolimbic dopaminergic system as an underlying factor for ethanol volition. Rats would try to ...
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Quintanilla González, María Elena; Tampier de Jong, Lutske (1992)The effect of a chronic ethanol consumption by forcing rats to drink a 20% v/v ethanol solution as sole drinking fluid, for 3 months, was evaluated on: liver and brain mitochondrial function, the capacity of isolated ...
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Karahanian, Eduardo; Quintanilla González, María Elena; Fernandez, Katia; Israel Jacard, Yedy (Elsevier Inc., 2014)© 2014 Elsevier Inc.The administration of disulfiram raises blood acetaldehyde levels when ethanol is ingested, leading to an aversion to alcohol. This study was aimed at assessing the effect of fenofibrate on voluntary ...
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Rivera Meza, Mario; Muñoz, Daniel; Jerez, Erik; Quintanilla González, María Elena; Salinas Luypaert, Catalina; Fernandez, Katia; Karahanian, Eduardo (Frontiers media SA, 2017)We have previously shown that the administration of fenofibrate to high-drinker UChB rats markedly reduces voluntary ethanol intake. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPAR a) agonist, which ...
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Muñoz, Daniel; Rivera Meza, Mario; Flores Bastías, Osvaldo; Quintanilla González, María Elena; Karahanian, Eduardo (Socidrogalcohol. Sociedad Científica Española de Estudio sobre el Alcohol, el Alcoholismo y las otras Toxocomanías, 2020)Tras consumir etanol, el disulfiram incrementa los niveles de acetaldehído en sangre y genera una reacción aversiva que desalienta el consumo de alcohol. Dados los importantes efectos secundarios del disulfiram, es ...
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Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
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Tampier de Jong, Lutske; Quintanilla González, María Elena; Mardones, Jorge (1981)The development of tolerance to ethanol was studied in two strains of rats, UChA (low ethanol consumer) and UChB (high ethanol consumer), by the sleeping time test. Marked tolerance (perhaps both metabolic and tissue) ...
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Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat Sapag Muñoz de la Peña, Amalia; Irarrázaval Aguilera, Thergiorg; Lobos González, Lorena; Muñoz Brauning, Carlos; Quintanilla González, María Elena; Tampier de Jong, Lutske (Nature Publishing Group, 2016)Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) ...
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Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Wiley, 2020)
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Israel Jacard, Yedy; Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario (2017)© The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved. Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats ...
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Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia Bustos, Andrea; Quintanilla González, María; Ezquer, Fernando; Valdés, José Luis; Israel Jacard, Yedy; Herrera Marschitz, Mario; Morales Retamales, Eugenia (2020)Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...