Browsing by Author "6ee196ae-21a4-4aae-952e-8f8f6488c69f"

Now showing items 1-6 of 6

    • Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition ... 
      Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model ... 
      Peredo Silva, Liliana; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Pavani Costa, Mario; Maya Arango, Juan; Castro Castillo, Vicente; Madrid Rojas, Matías; Rebolledo, Solange; Kemmerling Weis, Ulrike; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2017)
      We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
    • Destabilization of mitochondrial functions as a target against breast cancer progression: Role of ... 
      Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)
      Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
    • Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines 
      Jara Sandoval, José Antonio; Rojas Rivera, Diego; Castro Castillo, Vicente; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Parra, Eduardo; Pavani, Mario; Maya Arango, Juan Diego; Ferreira Parker, Jorge; Catalán Díaz, Mabel (Elsevier, 2020)
      Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
    • Simvastatin improves cardiac function through Notch 1 activation in BALB/c mice with Chronic Chagas Cardiomyopathy 
      Guzmán Rivera, Daniela; Liempi Manquel, Ana; González Herrera, Fabiola; Fuentes Retamal, Sebastián; Carrillo, Ileana; Abarca Bustos, Patricio; Castillo Rivas, Christian; Kemmerling Weis, Ulrike; Pesce Reyes, Bárbara; Maya Arango, Juan Diego (American Society for Microbiology (ASM), 2020)
      Chagas disease, caused by the protozoan Trypanosome cruzi, endemic in Latin America but distributed worldwide because of migration. Without appropriate treatment, the disease progresses from an acute asymptomatic phase to ...
    • The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition ... 
      Schmeda Hirschmann, Guillermo; Andrade, Jean Paulo de; Soto Vásquez, Marilu Roxana; Alvarado García, Paul Alan Arkin; Palominos, Charlotte; Fuentes Retamal, Sebastián; Mellado, Mathias; Correa, Pablo; Urra Faúndez, Félix (MDPI, 2020)
      Since Rhinella sp. toads produce bioactive substances, some species have been used in traditional medicine and magical practices by ancient cultures in Peru. During several decades, the Rhinella horribilis toad was confused ...