Browsing by Author "72f68b79-9043-400b-a961-38deba84141d"

Now showing items 1-5 of 5

    • An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry 
      Regan, Jennifer C.; Concha, Miguel L.; Roussigne, Myriam; Russell, Claire; Wilson, Stephen W. (2009)
      Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated ...
    • Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains 
      Kudoh, Tetsuhiro; Concha, Miguel L.; Houart, Corinne; Dawid, Igor B.; Wilson, Stephen W. (2004)
      Studies in fish and amphibia have shown that graded Bmp signalling activity regulates dorsal-to-ventral (DV) patterning of the gastrula embryo. In the ectoderm, it is thought that high levels of Bmp activity promote epidermal ...
    • Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field ... 
      Young, Rodrigo M.; Hawkins, Thomas A.; Cavodeassi, Florencia; Stickney, Heather L.; Schwarz, Quenten; Lawrence, Lisa M.; Wierzbicki, Claudia; Cheng, Bowie; Luo, Jingyuan; Ambrosio, Elizabeth Mayela; Klosner, Allison; Sealy, Ian M.; Rowell, Jasmine; Trivedi, Chintan A.; Bianco, Isaac H.; Allende Connelly, Miguel; Busch-Nentwich, Elisabeth M.; Gestri, Gaia; Wilson, Stephen W. (Elife Sciences Publ., 2019)
      The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a is one such transcription factor that acts cell-autonomously to ...
    • Encoding asymmetry within neural circuits 
      Concha, Miguel L.; Bianco, Isaac H.; Wilson, Stephen W. (2012)
      Genetic and environmental factors control morphological and functional differences between the two sides of the nervous system. Neural asymmetries are proposed to have important roles in circuit physiology, cognition and ...
    • Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis ... 
      Valdivia, Leonardo E.; Young, Rodrigo M.; Hawkins, Thomas A.; Stickney, Heather L.; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M.; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende Connelly, Miguel; Wilson, Stephen W. (2011)
      During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How tissues achieve this precise balance between proliferation and ...