Browsing by Author "73bd9745-56e2-4bf0-85dc-5fdbb753b74f"
Now showing items 1-9 of 9
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Cifuentes, Federico F.; Valenzuela, Rodrigo H.; Contreras, Héctor R.; Castellón, Enrique A. (Spandidos Publications, 2015)© 2015, Spandidos Publications. All rights reserved. Prostate cancer is one of the most prevalent oncological diseases in males worldwide, and the mortalities resulting from this type of cancer are mainly due to metastasis. ...
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Sánchez, Catherine; Mendoza, Patricia; Contreras, Héctor R.; Vergara, Jorge; McCubrey, James A.; Huidobro, Christian; Castellón, Enrique A. (2009)BACKGROUND. Multidrug resistance (MDR) proteins have been associated with the lack of chemotherapy response. Expression of these proteins has been described in the prostate, but there is no information about their role in ...
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Clementi, Marisa; Sánchez, Catherine; Benítez, Dixan A.; Contreras, Héctor R.; Huidobro, Christian; Cabezas, Juan; Acevedo, Cristian; Castellón, Enrique A. (Wiley, 2009)BACKGROUND. Gonadotropin-releasing-hormone (GnRH) analogs are widely used to block hypothalamic–pituitary–gonadal axis and inhibit blood androgen levels in patients with prostate cancer (PCa). In addition, GnRH analogs ...
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Castellón, Enrique A.; Valenzuela, Rodrigo; Lillo, Jorge; Castillo, Viviana; Contreras, Héctor R.; Gallegos, Iván; Mercado, Alejandro; Huidobro, Christian (2012)Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Chemotherapy response is very poor and resistance to hormone-based treatments is frequent in advances stages. Recently, tumor-initiating ...
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Sánchez, Catherine A.; Mercado, Alejandro J.; Contreras, Héctor R.; Cabezas, Juan C.; Huidobro, Christian C.; Castellón, Enrique A. (2012)Gonadotropin-releasing hormone (GnRH) agonists are widely used for the treatment of advanced prostate cancer (PCa). Agonists activate the GnRH receptor (GnRH-R), triggering apoptosis in PCa cells. In gonadotropes, the ...
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Benitez, Dixan A.; Hermoso Ramello, Marcela; Pozo-Guisado, Eulalia; Fernández-Salguero, Pedro M.; Castellón, Enrique A. (2009)BACKGROUND. Polyphenols have been proposed as antitumoral agents. We have shown that resveratrol (RES) induced cell cycle arrest and promoted apoptosis in prostate cancer cells by inhibition of the PI3K pathway. The RES ...
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Canesin, Giacomo; Maggio, Valentina; Palominos, Macarena; Stiehm, Anna; Contreras, Héctor R; Castellón, Enrique A.; Morote, Juan; Paciucci, Rosanna; Maitland, Norman J.; Bjartell, Anders; Hellsten, Rebecka (Nature Research, 2020)Cancer stem cells (CSCs) are a small subpopulation of quiescent cells with the potential to differentiate into tumor cells. CSCs are involved in tumor initiation and progression and contribute to treatment failure through ...
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Contreras, Hector R.; Ledezma, Rodrigo A.; Vergara, Jorge; Cifuentes, Federico; Barra, Cristina; Cabello, Pablo; Gallegos, Ivan; Morales, Bernardo; Huidobro, Christian; Castellón, Enrique A. (2010)The epithelial-mesenchymal transition (EMT) is considered a key step in tumor progression, where the invasive cancer cells change from epithelial to mesenchymal phenotype. During this process, a decrease or loss in adhesion ...
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Orellana-Serradell, Octavio; Herrera, Daniela; Castellón, Enrique A.; Contreras, Héctor R (NLM (Medline), 2019)One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition (EMT) program which has been associated with chemoresistance in tumoral cells. The transcription factor zinc ...