Browsing by Author "78f8f18c-a421-457c-b57a-42db5665953f"
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Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism Gallardo Garrido, C.; Cho, Y.; Cortés Ríos, J.; Vásquez Velásquez, David; Pessoa Mahana, C. David; Araya Maturana, R.; Pessoa Mahana, Hernán; Faúndez, M. (Elsevier, 2020)Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...
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Rodríguez Lavado, Julio; Gallardo Garrido, Carlos; Mallea Catalán, Michael; Bustos, Víctor; Osorio, Rodrigo; Hödar Salazar, Martín; Chung, Hery; Araya Maturana, Ramiro; Lorca, Marcos; Pessoa Mahana, C. David; Mella Raipán, Jaime; Saitz Barría, Claudio; Jaque Olmedo, Pablo; Reyes Parada, Miguel; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Hernán (Elsevier, 2020)During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer's disease and many others. In this context, the multitarget paradigm has ...