Browsing by Author "794ccd6d-d484-423d-8e45-fb5079865f4f"

Now showing items 1-3 of 3

    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 
      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • Astaxanthin counteracts excitotoxicity and reduces the ensuing increases in calcium levels and mitochondrial ... 
      García, Francisca; Lobos, Pedro; Ponce, Alejandra; Cataldo, Karla; Meza, Daniela; Farías, Patricio; Estay, Carolina; Oyarzún Ampuero, Felipe; Herrera Molina, Rodrigo; Paula Lima, Andrea; Ardiles, Álvaro O.; Hidalgo Tapia, Cecilia; Adasme, Tatiana; Muñoz, Pablo (MDPI, 2020)
      Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-beta peptide oligomers, which promote excessive ...
    • Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease 
      Muñoz, Pablo; Ardiles, Álvaro O.; Pérez Espinosa, Boris; Núñez Espinosa, Cristian; Paula Lima, Andrea; González Billault, Christian; Espinosa Parrilla, Yolanda (Elsevier, 2020)
      Aging is a natural process that includes several changes that gradually make organisms degenerate and die. Harman's theory proposes that aging is a consequence of the progressive accumulation of oxidative modifications ...