Browsing by Author "7999fea0-5272-470e-a8a3-fcd6004840d0"

Now showing items 1-12 of 12

    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ ... 
      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands ... 
      Aravena, Octavio; Pesce Reyes, Bárbara; Soto, Lilian; Orrego, Natalia; Sabugo, Francisca; Wurmann, Pamela; Molina, María Carmen; Alfaro, Jorge; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (2011)
      The aim of this work was to study the effect of anti-TNF treatment on CD4+ Th1, Th17 and regulatory T cells (Tregs), together with CD8+ T cells and NK cells from rheumatoid arthritis (RA) patients. For this purpose, 18 RA ...
    • Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic ... 
      Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Hager Ribeiro, Carolina; Molina, María C.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
    • Decreased invariant natural killer T-cell-mediated antitumor immune response in patients with gastric cancer 
      Ascui, Gabriel; Gálvez Jirón, Felipe; Kramm, Karina; Schafer, Carolina; Siña, Josefina; Pola, Víctor; Cristi, Francisca; Hernández, Carolina; Garrido Tapia, Macarena; Pesce Reyes, Bárbara; Bustamante Zamorano, Marco; Fluxá Rojas, Paula; Molina Sampayo, María Carmen; Ribeiro, Carolina H. (Wiley, 2020)
      Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Invariant natural killer T (iNKT) cells are innate-like cytotoxic T lymphocytes involved in tumor immune surveillance. They can be ...
    • Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells ... 
      García González, Paulina; Schinnerling, Katina; Sepúlveda Gutierrez, Alejandro; Maggi, Jaxaira; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce Reyes, Bárbara; Larrondo Lillo, Milton; Aravena, Octavio; Molina Sampayo, María Carmen; Catalán Martina, Diego; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media SA, 2017)
      There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a ...
    • Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic ... 
      Maggi, Jaxaira; Schinnerling, Katina; Pesce Reyes, Bárbara; Hilkens, Catharien M.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016)
      Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A (MPLA)-activated DCs [MPLA-tolerogenic DCs ...
    • In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin ... 
      Sosoniuk Roche, Eduardo Rodrigo; Cruz, Pamela; Maldonado, Ismael; Duaso, Leonora; Pesce Reyes, Bárbara; Michalak, Marek; Valck Calderón, Carolina Eliana; Ferreira Vigouroux, Arturo (Elsevier, 2020)
      American Trypanosomiasis, a parasitic disease produced by Trypanosoma cruzi (T. cruzi), endemic in Latin America, infects about 6 million people. During the chronic stage of the infection, approximately 30% of infected ...
    • Modulation of established murine collagen-induced arthritis by a single inoculation of short-term ... 
      Salazar, L.; Aravena, O.; Abello, P.; Escobar, A.; Contreras Levicoy, Juan; Rojas Colonelli, Nicole; Catalán Martina, Diego; Aguirre A., Luz María; Zúñiga, R.; Pesce Reyes, Bárbara; González, C.; Cepeda, R.; Cuchacovich Turteltaub, Miguel; Molina, M. C.; Salazar Onfray, Flavio; Delgado, M.; Toes, R. E.; Aguillón Gutiérrez, Juan Carlos (2008)
      Background: The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. Tumour necrosis factor (TNF)-stimulated DCs have been shown to restore tolerance ...
    • Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic ... 
      Salazar, Lorena; Aravena, Octavio; Contreras Levicoy, Juan; Pesce Reyes, Bárbara; Catalán Martina, Diego; Zúñiga, Roberto; Iruretagoyena, Mirentxu; Kalergis, Alexis M.; Aguillón Gutiérrez, Juan Carlos (2007)
      Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...
    • Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role ... 
      Campos Estrada, Carolina; Liempi, Ana; González Herrera, Fabiola; Lapier, Michel; Kemmerling Weis, Ulrike; Pesce Reyes, Bárbara; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Public Library of Science, 2015)
      © 2015 Campos-Estrada et al.Trypanosoma cruzi is the causal agent of Chagas Disease that is endemic in Latin American, afflicting more than ten million people approximately. This disease has two phases, acute and chronic. ...
    • Simvastatin improves cardiac function through Notch 1 activation in BALB/c mice with Chronic Chagas Cardiomyopathy 
      Guzmán Rivera, Daniela; Liempi Manquel, Ana; González Herrera, Fabiola; Fuentes Retamal, Sebastián; Carrillo, Ileana; Abarca Bustos, Patricio; Castillo Rivas, Christian; Kemmerling Weis, Ulrike; Pesce Reyes, Bárbara; Maya Arango, Juan Diego (American Society for Microbiology (ASM), 2020)
      Chagas disease, caused by the protozoan Trypanosome cruzi, endemic in Latin America but distributed worldwide because of migration. Without appropriate treatment, the disease progresses from an acute asymptomatic phase to ...
    • Treatment with dexamethasone and monophosphoryl lipid a removes disease-associated transcriptional signatures ... 
      García González, Paulina; Schinnerling, Katina; Sepúlveda Gutiérrez, Alejandro; Maggi, Jaxaira; Hoyos, Lorena; Morales, Rodrigo; Mehdi, Ahmed; Nel, Hendrik; Soto Sáez, Lilian; Pesce Reyes, Bárbara; Molina Sampayo, María Carmen; Cuchacovich Turteltaub, Miguel; Larrondo Lillo, Milton; Neira, Oscar; Catalán Martina, Diego; Hilkens, Catharien M.; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016-10-25)
      Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone ...