Browsing by Author "7cc1430b-c8cf-4bf9-be51-59b731c1dde5"

Now showing items 1-10 of 10

    • Cardiorespiratory functions in the fetal llama 
      Benavides, Claudio E.; Pérez, Rubén; Cerda Espinoza, Mauricio Alexis; Cabello, Gertrudis; Riquelme, Raquel; Parer, Julian T.; Llanos Mansilla, Jorge (1989)
      Factors which allow the adaptation of adult llamas to oxygen limitation include principally: low P50, small elliptical red cells with high hemoglobin concentration, high muscle myoglobin concentration, high capillary density ...
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Fetal cardiorespiratory changes during spontaneous prelabor uterine contractions in sheep 
      Llanos Mansilla, Jorge; Court, Denys J.; Block, Barry S.; Germain, Alfredo M.; Parer, Julian T. (1986)
      Fetal card iorespiratory changes during spontaneous prelabor uterine contractions (called contractures) were studied in 12 chronically catheterized fetal sheep at 120 to 143 days' gestation. During contractures the carcass ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension ... 
      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Regional brain blood flow and cerebral hemispheric oxygen consumption during acute hypoxaemia in the Ilama fetus 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Sanhueza, Emilia M.; Herrera Videla, Emilio; Cabello, Gertrudis; Giussani, Dino A.; Parer, Julian T. (2002)
      Unlike fetal animals of lowland species, the llama fetus does not increase its cerebral blood flow during an episode of acute hypoxaemia. This study tested the hypothesis that the fetal llama brain maintains cerebral ...
    • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs 
      López, Nandy; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, Roberto V.; Calaf, Gloria; Cabello, Gertrudis; Moraga, Fernando; Benaldo, Felipe A.; Díaz, Marcela; Parer, Julian T.; Llanos Mansilla, Jorge (Amer Physiological Soc, 2016)
      Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, ...
    • Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: A comparative ... 
      Moraga, Fernando A.; Reyes, Roberto V.; Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Pulgar, Víctor M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2011)
      Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
    • Sildenafil Reverses Hypoxic Pulmonary Hypertension in Highland and Lowland Newborn Sheep 
      Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Riquelme González, Raquel; Reyes, Roberto V.; Capetillo, María; González, Sergio; Parer, Julian T.; Llanos Mansilla, Jorge (International Pediatric Research Foundation, Inc., 2008)
      Perinatal exposure to chronic hypoxia induces sustained hypertension and structural and functional changes in the pulmonary vascular bed. We hypothesized that highland newborn lambs (HLNB, 3600 m) have a higher pulmonary ...
    • The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas 
      Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...