Now showing items 1-14 of 14

    • Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)
      A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
    • Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado Maldonado, Edio (Public Library Science, 2018)
      Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
    • Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado, Edio (Public Library of Science, 2018)
      © 2018 Rojas et al. Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and ...
    • Lapier, Michel; Zúñiga López, María C.; Aguilera Venegas, Benjamín; Adam, Rosa; Abarca, Belén; Ballesteros, Rafael; López Muñoz, Rodrigo; Maya Arango, Juan; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
    • Moncada-Basualto, Mauricio; Lapier, Michel; Maya Arango, Juan; Matsuhiro, Betty; Olea Azar, Claudio; Delogu, Giovanna; Uriarte, Eugenio; Santana, Lourdes; João Matos, María (Bentham Science, 2018)
      Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
    • Pérez Cruz, Fernanda; Aguilera Venegas, Benjamín; Lapier, Michel; Sobarzo Sánchez, Eduardo; Uriarte Villares, Eugenio; Olea Azar, Claudio (2013)
      A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O- ...
    • Rodríguez Arce, Esteban; Putzu, Eugenia; Lapier, Michel; Maya Arango, Juan; Olea Azar, Claudio; Echeverría, Gustavo A.; Piro, Oscar E.; Medeiros, Andrea; Sardi, Florencia; Comini, Marcelo; Risi, Gastón; Salinas, Gustavo; Correia, Isabel; Pessoa, João Costa; Otero, Lucía (Royal Society of Chemistry, 2019)
      In the search for a more effective chemotherapy for the treatment of Chagas' disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic ...
    • Seguel, Verónica; Castro, Lorena; Reigada, Chantal; Leonel, Cortés; Miranda., Mariana R.; Pereira, Claudio A.; Lapier, Michel; Campos Estrada, Carolina; Morello Casté, Antonio (Academic Press Inc Elsevier Science, 2016-12)
      Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. Pentamidine is ...
    • Seguel, Verónica; Castro, Lorena; Reigada, Chantal; Cortes, Leonel; Díaz, María V.; Miranda, Mariana R.; Pereira, Claudio A.; Lapier, Michel; Campos Estrada, Carolina; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; López Muñoz, Rodrigo (Academic Press Inc., 2016)
      © 2016 Elsevier Inc.Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. ...
    • Rodríguez Arce, Esteban; Machado, Ignacio; Rodríguez, Belén; Lapier, Michel; Zúñiga, María Carolina; Maya Arango, Juan; Olea Azar, Claudio; Otero, Lucía; Gambino, Dinorah (Elsevier Inc., 2017)
      © 2017 Elsevier Inc. American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects ...
    • Campos Estrada, Carolina; Liempi, Ana; González Herrera, Fabiola; Lapier, Michel; Kemmerling Weis, Ulrike; Pesce Reyes, Bárbara; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Public Library of Science, 2015)
      © 2015 Campos-Estrada et al.Trypanosoma cruzi is the causal agent of Chagas Disease that is endemic in Latin American, afflicting more than ten million people approximately. This disease has two phases, acute and chronic. ...
    • Urra Faúndez, Félix; Córdova Delgado, Miguel; Lapier, Michel; Orellana Manzano, Andrea; Acevedo Arévalo, Luis; Pessoa Mahana, Hernán; González Vivanco, Jaime; Martínez Cifuentes, Maximiliano; Ramírez Rodríguez, Oney; Millas Vargas, Juan; Weiss López, Boris; Pavani, Mario; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Academic Press Elsevier Science, 2016)
      Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
    • Robledo O'Ryan, Natalia Carolina; Moncada-Basualto, Mauricio; Mura, Francisco; Olea Azar, Claudio; Matos, Maria João; Vazquez-Rodriguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; ; Lapier, Michel; Maya Arango, Juan (Elsevier Ltd, 2017)
      © 2016 Elsevier Ltd Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents ...
    • Jaña, Fabián; Faini, Francesca; Lapier, Michel; Pavani, Mario; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Jara, José; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2013)
      Changes in mitochondrial ATP synthesis can affect the function of tumor cells due to the dependence of the first step of glycolysis on mitochondrial ATP. The oxidative phosphorylation (OXPHOS) system is responsible for ...