Browsing by Author "804c0600-0ae1-4606-8076-e766669fc353"

Now showing items 1-10 of 10

    • Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic ... 
      Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)
      A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
    • Evaluation of the novel antichagasic activity of [1,2,3]triazolo[1,5-a]pyridine derivatives 
      Lapier, Michel; Zúñiga López, María C.; Aguilera Venegas, Benjamín; Adam, Rosa; Abarca, Belén; Ballesteros, Rafael; López Muñoz, Rodrigo; Maya Arango, Juan; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
    • Evaluation of trypanocidal and antioxidant activities of a selected series of 3-amidocoumarins 
      Moncada-Basualto, Mauricio; Lapier, Michel; Maya Arango, Juan; Matsuhiro, Betty; Olea Azar, Claudio; Delogu, Giovanna; Uriarte, Eugenio; Santana, Lourdes; João Matos, María (Bentham Science, 2018)
      Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
    • Host-guest interaction between new nitrooxoisoaporphine and β-cyclodextrins: Synthesis, electrochemical, ... 
      Pérez Cruz, Fernanda; Aguilera Venegas, Benjamín; Lapier, Michel; Sobarzo Sánchez, Eduardo; Uriarte Villares, Eugenio; Olea Azar, Claudio (2013)
      A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O- ...
    • New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents 
      Rodríguez Arce, Esteban; Putzu, Eugenia; Lapier, Michel; Maya Arango, Juan; Olea Azar, Claudio; Echeverría, Gustavo A.; Piro, Oscar E.; Medeiros, Andrea; Sardi, Florencia; Comini, Marcelo; Risi, Gastón; Salinas, Gustavo; Correia, Isabel; Pessoa, João Costa; Otero, Lucía (Royal Society of Chemistry, 2019)
      In the search for a more effective chemotherapy for the treatment of Chagas' disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic ...
    • Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity ... 
      Rodríguez Arce, Esteban; Machado, Ignacio; Rodríguez, Belén; Lapier, Michel; Zúñiga, María Carolina; Maya Arango, Juan; Olea Azar, Claudio; Otero, Lucía; Gambino, Dinorah (Elsevier Inc., 2017)
      © 2017 Elsevier Inc. American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects ...
    • Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role ... 
      Campos Estrada, Carolina; Liempi, Ana; González Herrera, Fabiola; Lapier, Michel; Kemmerling Weis, Ulrike; Pesce Reyes, Bárbara; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Public Library of Science, 2015)
      © 2015 Campos-Estrada et al.Trypanosoma cruzi is the causal agent of Chagas Disease that is endemic in Latin American, afflicting more than ten million people approximately. This disease has two phases, acute and chronic. ...
    • Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of ... 
      Urra Faúndez, Félix; Córdova Delgado, Miguel; Lapier, Michel; Orellana Manzano, Andrea; Acevedo Arévalo, Luis; Pessoa Mahana, Hernán; González Vivanco, Jaime; Martínez Cifuentes, Maximiliano; Ramírez Rodríguez, Oney; Millas Vargas, Juan; Weiss López, Boris; Pavani, Mario; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Academic Press Elsevier Science, 2016)
      Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
    • Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins 
      Robledo O'Ryan, Natalia Carolina; Moncada-Basualto, Mauricio; Mura, Francisco; Olea Azar, Claudio; Matos, Maria João; Vazquez-Rodriguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; ; Lapier, Michel; Maya Arango, Juan (Elsevier Ltd, 2017)
      © 2016 Elsevier Ltd Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents ...
    • Tumor cell death induced by the inhibition of mitochondrial electron transport: The effect of 3-hydroxybakuchiol 
      Jaña, Fabián; Faini, Francesca; Lapier, Michel; Pavani, Mario; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Jara, José; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2013)
      Changes in mitochondrial ATP synthesis can affect the function of tumor cells due to the dependence of the first step of glycolysis on mitochondrial ATP. The oxidative phosphorylation (OXPHOS) system is responsible for ...