Browsing by Author "81c10b68-4e65-41fd-a471-906871f42b2a"

Now showing items 1-6 of 6

    • Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function 
      Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)
      To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
    • Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels ... 
      Cea Pisani, Luis Andrés; Puebla, Carlos; Cisterna, Bruno A.; Escamilla, Rosalba; Vargas, Anibal A.; Frank, Marina; Martinez Montero, Paloma; Prior, Carmen; Molano, Jesus; Esteban Rodríguez, Isabel; Pascual, Ignacio; Gallano, Pía; Lorenzo, Gustavo; Pian, Héctor; Barrio, Luis C.; Willecke, Kla; Saez, Juan C. (Springer, 2016)
      Skeletal muscles of patients with Duchenne muscular dystrophy (DMD) show numerous alterations including inflammation, apoptosis, and necrosis of myofibers. However, the molecular mechanism that explains these changes remains ...
    • Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture 
      Figueroa, Xavier F.; Alviña, Karina; Martínez, Agustín D.; Garcés, Gladys; Rosemblatt Silber, Mario César; Boric, Mauricio P.; Sáez, Juan C. (Academic Press Inc., 2004)
      The regulation of gap junctional communication by histamine was studied in primary cultures of human tonsil high endothelial cells (HUTECs). We evaluated intercellular communication, levels, state of phosphorylation, and ...
    • Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic ... 
      Fernández, Gabriela; Arias Bravo, Guisselle; Bevilacqua, Jorge A.; Castillo Ruíz, Mario; Caviedes Fernández, Pablo; Sáez, Juan C.; Cea, Luis A. (Elsevier, 2020)
      Dysferlinopathy is a genetic human disease caused by mutations in the gene that encodes the dysferlin protein (DYSF). Dysferlin is believed to play a relevant role in cell membrane repair. However, in dysferlin-deficient ...
    • Sepsis induced channelopathy in skeletal muscles is associated with expression of non selective channels 
      Balboa, Elisa; Saavedra Leiva, Fujiko; Cea Pisani, Luis Andrés; Vargas, Anibal A.; Ramírez, Valeria; Escamilla, Rosalba; Saez, Juan C.; Regueira, Tomás (Lippincott Williams & Wilkins, 2018)
      Skeletal muscles (similar to 50% of the body weight) are affected during acute and late sepsis and represent one sepsis associate organ dysfunction. Cell membrane changes have been proposed to result from a channelopathy ...
    • The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes 
      Cea Pisani, Luis Andrés; Bevilacqua, Jorge; Arriagada Abarzúa, Christian; Cárdenas, Ana María; Bigot, Anne; Mouly, Vincent; Sáez, Juan C.; Caviedes Fernández, Pablo (2016)
      Background: Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, ...