Browsing by Author "828f3d0c-ecf3-4563-a51b-80627e65727b"
Now showing items 1-8 of 8
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Acuña Castillo, Claudio; Scorza, Cecilia; Reyes Parada, Miguel; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Elsevier Science Inc., 2000-06-06)To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either of the rat cRNA for the ...
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Donoso, M. V.; Carvajal, A.; Paredes Vargas, Alfonso; Tomic, A.; Koenig, Cecilia S.; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE INC, 2002-09)Neuropeptide Y (NPY) and noradrenaline (NA) are co-transmitters at many sympathetic synapses, but it is not yet clear if their release is independently regulated. To address this question, we quantified the electrically ...
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Robles Planells, Claudia; Barrera Ávalos, Carlos; Rojo, Leonel E.; Spencer, Eugenio; Cortez San Martín, Eugenio; Matiacevich, Silvia; Pavez, Jorge; Milla, Luis A.; Navarro, Franco D.; Martínez, Brandon A; Bravo, Francisco J.; Mella, Andrea; Huidobro Toro, Juan Pablo; Fernández, Ricardo; Escobar Álvarez, Alejandro; Acuña Castillo, Claudio (Hindawi, 2020)Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune ...
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Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
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Acuña Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R.; Sáez, Patricio; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Nature Publishing Group, 2002-04-04)1 The pharmacological pro®le of a series of (+)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding ...
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Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves Boric, M. P.; Figueroa, X. F.; Donoso, M. V.; Paredes Vargas, Alfonso; Poblete, I.; Huidobro Toro, Juan Pablo (AMER PHYSIOLOGICAL SOC, 1999-09)To evaluate whether sympathetic activity induces nitric oxide (NO) production, we perfused the rat arterial mesenteric bed and measured luminally accessible norepinephrine (NE), NO, and cGMP before, during, and after ...
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Ferrada, Evandro; Arancibia, Verónica; Loeb, Bárbara; Norambuena, Ester; Olea Azar, Claudio; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE BV, 2007-05)Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer’s disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of ...
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Riquelme, Denise; Silva, Ian; Philp, Ashleigh M.; Huidobro Toro, Juan Pablo; Cerda, Oscar; Trimmer, James; Leiva Salcedo, Elías (Frontiers Media SA, 2018)TRPM4 is a Ca2+-activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained activity in several brain regions, however, the cellular and ...