Browsing by Author "8f278acc-6445-4fcc-8347-9c8fed72aa15"

Now showing items 1-7 of 7

    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome. 
      Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Salivary gland ...
    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA ... 
      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 
      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to ... 
      Ewert, Patricia; Aguilera, Sergio; Alliende, Cecilia; Kwon, Yoon Jeoung; Albornoz, Amelina; Molina, Claudio; Urzúa, Ulises; Quest, Andrew F. G.; Olea, Nancy; Pérez, Paola; Castro, Isabel; Barrera, María José; Romo, Rafael; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Mar (2010)
      Objective. Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's ...
    • Gene expression and chromosomal location for susceptibility to Sjögren's syndrome 
      Pérez, Paola; Anaya, Juan Manuel; Aguilera, Sergio; Urzúa Tobar, Ulises; Munroe, David; Molina, Claudio; Hermoso Ramello, Marcela; Cherry, James Michael; Alliende, Cecilia; Olea, Nancy; Ruiz-Narváez, Edward; González Burgos, María Julieta (2009)
      Primary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory ...
    • Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary ... 
      Kwon, Yoon Jeoung; Pérez, Paola; Aguilera, Sergio; Molina, Claudio; Leyton Campos, Lisette; Alliende, Cecilia; Leyton, Cecilia; Brito, Mónica; Romo, Rafael; González Burgos, María Julieta (2006)
      Objective. To investigate remodeling of the basal lamina of labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) by analyzing the expression of specific components that participate in its assembly and ...
    • T cell exosome–derived miR-142-3p impairs glandular cell function in Sjögren’s syndrome 
      Cortes Troncoso, Juan; Jang, Shyh-Ing; Pérez, Paola; Hidalgo, Jorge; Ikeuchi, Tomoko; Greenwell-Wild, Teresa; Warner, Blake M.; Moutsopoulos, Niki M.; Alevizos, Ilias (The American Society for Clinical Investigation, 2020)
      Sjogren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. ...