Browsing by Author "92eb28bd-5357-494d-b97e-498d35bb4427"

Now showing items 1-11 of 11

    • A software to prevent delirium in hospitalised older adults: development and feasibility assessment 
      Álvarez Espinoza, Evelyn; Garrido Montenegro, Maricel; Ponce, Daniela P.; Pizarro, Gaspar; Córdova, Andrés A.; Vera, Felipe; Ruiz, Rocío; Fernández, Raúl; Velásquez Silva, Juan; Tobar Almonacid, Eduardo (Oxford Univ Press, 2020)
      Background: non-pharmacological interventions to prevent delirium are useful in hospitalised older adults. However, they are poorly implemented in clinical practice. We aimed to develop a software for bedside use by ...
    • CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and ... 
      Ponce, Daniela P.; Yefi, Roger; Cabello, Pablo; Maturana, Jose L.; Niechi, Ignacio; Silva, Eduardo; Galindo, Mario; Antonelli, Marcelo; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Tapia, Julio C. (2011)
      β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
    • Consolidated framework for advancing implementation science for the implementation process and adherence ... 
      Garrido Montenegro, Maricel; Álvarez Espinoza, Evelyn; Ponce, Daniela P.; Salech Morales, Felipe; Tobar, Daniel I.; Tobar Almonacid, Eduardo (Wiley, 2020)
      Objective To evaluate the contribution of applying the theoretical framework of implementation science for adherence to non-pharmacological interventions to prevent delirium. Methods A quasi-experimental prospective design ...
    • Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia ... 
      Ponce, Daniela P.; Salech Morales, Felipe; San Martín Rovirosa, Carol; Silva, Monica; Xiong, Chengjie; Roe, Catherine M.; Henríquez, Mauricio; Quest, Andrew F. G.; Behrens Pellegrino, María Isabel (Bentham Science Publishers B.V., 2014)
      © 2014 Bentham Science Publishers.We previously reported on enhanced susceptibility to death of lymphocytes from Alzheimer’s disease (AD) patients when exposed to hydrogen peroxide (H2O2)-induced oxidative stress and an ...
    • Inverse relationship between alzheimer's disease and cancer: How immune checkpoints might explain the ... 
      Rogers Castillo, Nicole K.; Romero, César A.; San Martín Rovirosa, Carol D.; Ponce, Daniela P.; Salech Morales, Felipe; López, Mercedes N; Gleisner, Alejandra; Tempio Sepúlveda, Fabián; Behrens Pellegrino, María I. (IOS Press, 2020)
      Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the adult population. There is evidence of an inverse epidemiological relationship between AD and cancer, another prevalent age-related disease. ...
    • Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer ... 
      Behrens Pellegrino, María Isabel; Silva, Monica; Salech Morales, Felipe; Ponce, Daniela P.; Merino, Daniela; Sinning, Mariana; Xiong, Chengjie; Roe, Catherine M.; Quest, Andrew F. G. (2012)
      A paucity of cancer in individuals with Alzheimer's disease (AD) and low rates of AD in cancer survivors has been reported in epidemiological studies. Deregulation in opposite directions of biological mechanisms, such as ...
    • Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of ... 
      Pérez, María José; Ponce, Daniela P.; Aranguiz, Alejandra; Behrens Pellegrino, María Isabel; Quintanilla, Rodrigo A. (Elsevier B.V., 2018)
      © 2018 The Authors In the last few decades, many reports have suggested that mitochondrial function impairment is a hallmark of Alzheimer's disease (AD). Although AD is a neurodegenerative disorder, mitochondrial damage ...
    • PARP-1 and p53 regulate the increased susceptibility to oxidative death of lymphocytes from MCI and AD patients 
      Salech Morales, Felipe; Ponce, Daniela P.; San Martín Rovirosa, Carol; Rogers Castillo, Nicole; Chacón, Carlos; Henriquez Luna, Mauricio; Behrens Pellegrino, María Isabel (Frontiers media SA, 2017)
      Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in ...
    • Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional ... 
      Ponce, Daniela P.; Maturana, Jose L.; Cabello, Pablo; Yefi, Roger; Niechi, Ignacio; Silva, Eduardo; Armisen Yáñez, Ricardo; Galindo, Mario; Antonelli, Marcelo; Tapia, Julio C. (2011)
      β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the ...
    • Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and ... 
      Yefi, Roger; Ponce, Daniela P.; Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Rodriguez, Diego A.; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Quest, Andrew F. G.; Tapia, Julio C. (2011)
      Augmented expression of protein kinase CK2 is associated with hyperproliferation and resistance to apoptosis in cancer cells. Effects of CK2 are at least partially linked to signaling via the Wnt/β-catenin pathway, which ...
    • Vitamin D increases A beta 140 Plasma levels and protects Lymphocytes from oxidative death in mild cognitive ... 
      San Martín Rovirosa, Carol; Henriquez Luna, Mauricio; Chacon, Carlos; Ponce, Daniela P.; Salech Morales, Felipe; Rogers Castillo, Nicole; Behrens Pellegrino, María Isabel (2018)
      Background: Mild cognitive impairment (MCI) has an increased rate of progression to dementia. Alterations of some metabolic factors, such as deficiency of vitamin D, are a risk factor for cognitive deterioration. Vitamin ...