Browsing by Author "959650a3-43ab-42a1-9fc3-7331c875cca8"

Now showing items 1-3 of 3

    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Interleukin-6 and lipopolysaccharide modulate hepcidin mRNA expression by Hepg2 cells 
      Villarroel, Pia; Le Blanc, Solange; Arredondo, Miguel (2012)
      Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways. Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear. We studied the modulatory ...
    • Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and ... 
      Blanc, Solange Le; Villarroel, Pia; Candia, Valeria; Gavilán, Natalia; Soto, Néstor; Pérez Bravo, Francisco; Arredondo, Miguel (2012)
      Type 2 diabetes (T2D) is directly related to alterations in iron status, oxidative stress and decreased mitochondrial activity, but the possible interaction of these parameters among T2D patients and their offspring is ...