Browsing by Author "95e2d6a0-2c8a-4161-9bbc-19f83d4c97aa"

Now showing items 1-8 of 8

    • A short hairpin RNA-based adjuvant targeting NF-kappa B repressor I kappa B alpha promotes migration of ... 
      Gálvez Cancino, Felipe; Roco, Jonathan; Rojas Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz Gómez, Sebastián; Oyarce, Cesar; Varas Godoy, Manuel; Sauma Mahaluf, Daniela; Lladser, Álvaro (Elsevier, 2017)
      DNA vaccination is an attractive approach to elicit tumor-specific cytotoxic CD8(+) T lymphocytes (CTL), which can mediate protective immunity against tumors. To initiate CTL responses, antigen-encoding plasmids employed ...
    • Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph ... 
      Oyarce, César; Cruz Gómez, Sebastián; Gálvez Cancino, Felipe Ignacio; Vargas, Pablo; Moreau, Hélène D.; Díaz Valdivia, Natalia; Díaz, Jorge; Salazar Onfray, Flavio; Pacheco, Rodrigo; Lennon Duménil, Ana María; Quest, Andrew F. G.; Lladser, Álvaro (Frontiers Media, 2017)
      Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the ...
    • Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional ... 
      Sanhueza, Carlos; Castillo Bennett, Jimena; Valenzuela Valderrama, Manuel; Contreras, Pamela; Lobos González, Lorena; Campos, América; Wehinger, Sergio; Lladser, Álvaro; Kiessling, Rolf; Leyton Campos, Lisette; Quest, Andrew F. G. (MDPI, 2020)
      Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
    • Dopamine Receptor D3 Signaling on CD4(+) T Cells Favors Th1-and Th17-Mediated Immunity 
      Contreras, Francisco; Prado, Carolina; González, Hugo; Franz, Dafne; Osorio Barrios, Francisco; Osorio Olivares, Fabiola; Ugalde, Valentina; López, Ernesto; Elgueta, Daniela; Figueroa, Alicia; Lladser, Álvaro; Pacheco, Rodrigo (Amer Assoc Immunologists, 2016)
      Dopamine receptor D3 (DRD3) expressed on CD4(+) T cells is required to promote neuroinflammation in a murine model of Parkinson's disease. However, how DRD3 signaling affects T cell-mediated immunity remains unknown. In ...
    • In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo 
      Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)
      Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
    • In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma ... 
      Varas Godoy, Manuel; Lladser, Álvaro; Farfan, Nicole; Villota, Claudio; Villegas, Jaime; Tapia Pineda, Julio; Burzio, Luis O.; Burzio, Verónica A.; Valenzuela, Pablo D. T. (Wiley, 2018)
      The family of non-coding mitochondrial RNAs (ncmtRNA) is differentially expressed according to proliferative status. Normal proliferating cells express sense (SncmtRNA) and antisense ncmtRNAs (ASncmtRNAs), whereas tumor ...
    • Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection ... 
      Lladser, Álvaro; Ljungberg, Karl; Tufvesson, Helena; Tazzari, Marcella; Roos, Anna Karin; Quest, Andrew F. G.; Kiessling, Rolf (2010)
      Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiated tissues. Naked DNA vaccines ...
    • Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and ... 
      Lladser, Álvaro; Párraga, Mario; Quevedo, Licarallén; Molina, Maria Carmen; Silva, Soledad; Ferreira, Arturo; Billetta, Rosario; Quest, Andrew F. G. (Elsevier GmbH, 2006)
      Survivin, a 16.5 kDa tumor associated antigen, is the smallest member of the inhibitor of apoptosis family that is abundantly expressed during development but essentially absent in normal adult tissues. Interestingly, ...