Browsing by Author "9629e615-685c-417c-9e8f-3f4747a6e603"

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    • Intrinsically Disordered Regions of the DNABinding Domain of Human FoxP1 Facilitate Domain Swapping 
      Medina, Exequiel; Torres Villalobos, Pablo; Hamilton, George L.; Komives, Elizabeth A.; Sanabria, Hugo; Ramírez Sarmiento, César A.; Babul, Jorge (Elsevier, 2020)
      Forkhead box P (FoxP) proteins are unique transcription factors that spatiotemporally regulate gene expression by tethering two chromosome loci together via functional domain-swapped dimers formed through their ...
    • Tuning of conformational dynamics through evolution-based design modulates the catalytic adaptability of ... 
      Zamora, Ricardo A.; Ramírez Sarmiento, César; Castro Fernández, Víctor; Villalobos, Pablo; Maturana, Pablo; Herrera Morandé, Alejandra; Komives, Elizabeth A.; Guixe, Victoria (American Chemical Society, 2020)
      Conformational flexibility plays a critical role in enzyme function and is a key aspect in transitions from an open to a closed state induced by substrate binding and product release. Psychrophilic enzymes display a high ...