Browsing by Author "966cdd3a-f2a0-41ea-a84f-acd34f04b69f"
Now showing items 1-13 of 13
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(Frontiers Media, 2014)Schizophrenia and Alzheimer’s disease are two disorders that, while conceptualized as pathophysiologically and clinically distinct, cause substantial cognitive and behavioral impairment worldwide, and target apparently ...
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(Hindawi, 2020)Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune ...
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(Hindawi, 2020)Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
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(Frontiers media SA, 2017)Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
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(Frontiers Media, 2016)Metabolic syndrome (MS) is a prevalent and severe comorbidity observed in schizophrenia (SZ). The exact nature of this association is controversial and very often accredited to the effects of psychotropic medications and ...
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(BENTHAM SCIENCE PUBL LTD, 2008-10)Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for Alzheimer´s disease (AD). However, the molecular and cellular basis that link insulin resistance disorders and diabetes with AD are far ...
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(Frontiers Media SA, 2018)Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
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(Frontiers Media, 2020)A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
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Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron (IOS PRESS, 2008)Oxidative stress constitutes a hallmark of Alzheimer’s disease (AD). Recent studies also point to redox active metals such as iron, copper and zinc in mediating oxidative stress in AD pathogenesis. However, the reactivity ...
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(IOS Press, 2020)Background: Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free ...
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Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease (2008)During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
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(IOS Press, 2010)We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important ...
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(IOS Press, 2020)One of the major challenges of medical sciences has been finding a reliable compound for the pharmacological treatment of Alzheimer's disease (AD). As most of the drugs directed to a variety of targets have failed in finding ...
