Browsing by Author "96aa4206-c32a-46e2-a1d4-a70492bfdbe2"

Now showing items 1-7 of 7

    • Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents ... 
      Ayala, Pedro; Montenegro, José; Vivar, Raúl; Letelier, Alan; Urroz, Pablo Aránguiz; Copaja, Miguel; Pivet, Deisy; Humeres, Claudio; Troncoso, Rodrigo; Vicencio, José Miguel; Lavandero González, Sergio; Díaz Araya, Guillermo (2012)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein ...
    • Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte ... 
      Humeres, Claudio; Vivar, Raúl; Boza Fuentes, Pía; Muñoz, Claudia; Bolivar, Samir; Anfossi, Renatto; Osorio, Jose Miguel; Olivares Silva, Francisco Javier; García Nannig, Lorena; Díaz Araya, Guillermo (Academic Press, 2016)
      © 2016 Elsevier Ltd Macrophage polarization plays an essential role in cardiac remodeling after injury, evolving from an initial accumulation of proinflammatory M1 macrophages to a greater balance of anti-inflammatory M2 ...
    • Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and ... 
      Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza Fuentes, Pía; Muñoz, Claudia; Díaz Araya, Guillermo (2012)
      Cardiac fibroblast (CF) death by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. Although IGF-1 has well-known cytoprotective effects, no study has been done on CF subjected to simulated ...
    • FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation 
      Vivar, Raúl; Humeres, Claudio; Muñoz, Claudia; Boza Fuentes, Pía; Bolivar, Samir; Tapia, Felipe; Lavandero González, Sergio; Chiong Lay, Mario; Díaz Araya, Guillermo (Elsevier, 2016)
      © 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
    • Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death 
      Díaz, Ariel; Humeres, Claudio; González, Verónica; Gómez, María Teresa; Montt, Natalia; Sánchez, Gina; Chiong Lay, Mario; García Nannig, Lorena (Academic Press Inc., 2015)
      In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
    • Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1 
      Vivar Sánchez, Raúl; Humeres, Claudio; Anfossi, Renatto; Bolívar, Samir; Catalán Díaz, Mabel; Hill, Joseph; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2020)
      Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
    • TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both ... 
      Vivar, Raúl; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalán, Mabel; García Nannig, Lorena; Lavandero González, Sergio; Díaz Araya, Guillermo (2013)
      Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...