Now showing items 1-11 of 11

    • Ayala, Pedro; Montenegro, José; Vivar, Raúl; Letelier, Alan; Urroz, Pablo Aránguiz; Copaja, Miguel; Pivet, Deisy; Humeres, Claudio; Troncoso, Rodrigo; Vicencio, José Miguel; Lavandero González, Sergio; Díaz Araya, Guillermo (2012)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein ...
    • Humeres, Claudio; Vivar, Raúl; Boza Fuentes, Pía; Muñoz, Claudia; Bolivar, Samir; Anfossi, Renatto; Osorio, Jose Miguel; Olivares Silva, Francisco Javier; García Nannig, Lorena; Díaz Araya, Guillermo (Academic Press, 2016)
      © 2016 Elsevier Ltd Macrophage polarization plays an essential role in cardiac remodeling after injury, evolving from an initial accumulation of proinflammatory M1 macrophages to a greater balance of anti-inflammatory M2 ...
    • Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza Fuentes, Pía; Muñoz, Claudia; Díaz Araya, Guillermo (2012)
      Cardiac fibroblast (CF) death by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. Although IGF-1 has well-known cytoprotective effects, no study has been done on CF subjected to simulated ...
    • Muñoz Rodríguez, Claudia Muriel; Fernández, Samuel; Osorio, José Miguel; Olivares, Francisco; Anfossi, Renatto; Bolivar, Samir; Humeres, Claudio; Boza Fuentes, Pía; Vivar, Raúl; Pardo Jiménez, Viviana Gladys; Hemmings, Karen E.; Turner, Neil A.; Díaz Araya, Guillermo (Academic Press Inc., 2018)
      © 2018 Elsevier Inc. Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. ...
    • Muñoz Rodríguez, Claudia Muriel; Fernández, Samuel; Osorio, José Miguel; Ritchie Olivares, Francisco Antonio; Anfossi, Renatto; Bolivar, Samir; Humeres, Claudio; Boza Fuentes, Pía; Vivar, Raúl; Pardo Jiménez, Viviana Gladys; Hemmings, Karen E.; Turner, Neil A.; Díaz Araya, Guillermo (Elsevier, 2018-07-15)
      Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. Additionally, CF play ...
    • Muñoz Rodríguez, Claudia Muriel; Fernández, Samuel; Osorio, Jose Miguel; Olivares, Francisco; Anfossi, Renatto; Bolivar, Samir; Humeres, Claudio; Boza Fuentes, Pía; Vivar, Raúl; Pardo Jiménez, Viviana Gladys; Hemmings, Karen E.; Turner, Neil A.; Díaz Araya, Guillermo (Elsevier, 2018-07-15)
      Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. Additionally, CF play ...
    • Boza Fuentes, Pía; Ayala, Pedro; Vivar, Raúl; Humeres, Claudio; Cáceres, Felipe Tapia; Muñoz, Claudia; García Nannig, Lorena; Hermoso, Marcela A.; Díaz-Araya, Guillermo (Elsevier Ltd, 2016)
      © 2016 Elsevier Ltd. Cardiac inflammation can be produced by pathogen-associated molecular patterns (PAMPs), from parasitic, bacterial or viral origin; or by danger-associated molecular patterns (DAMPs), released from dead ...
    • Vivar, Raúl; Humeres, Claudio; Muñoz, Claudia; Boza Fuentes, Pía; Bolivar, Samir; Tapia, Felipe; Lavandero González, Sergio; Chiong Lay, Mario; Díaz Araya, Guillermo (Elsevier, 2016)
      © 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
    • Díaz, Ariel; Humeres, Claudio; González, Verónica; Gómez, María Teresa; Montt, Natalia; Sánchez, Gina; Chiong Lay, Mario; García Nannig, Lorena (Academic Press Inc., 2015)
      In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
    • Vivar Sánchez, Raúl; Humeres, Claudio; Anfossi, Renatto; Bolívar, Samir; Catalán Díaz, Mabel; Hill, Joseph; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2020)
      Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
    • Vivar, Raúl; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalán, Mabel; García Nannig, Lorena; Lavandero González, Sergio; Díaz Araya, Guillermo (2013)
      Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...