Browsing by Author "9a927ae3-ad50-4c99-a7ff-7fb064ab74f4"

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    • Defect in ERK2 and p54JNK activation in aging mouse splenocytes 
      Li, Min; Torres, Claudio; Acuña Castillo, Claudio; Walter, Robin Ann; Gardner, Elizabeth M.; Murasko, Donna M.; Sierra, Felipe (2002)
      We have previously reported on a defect in both extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation in splenocytes obtained from old rats. ...
    • Increased expression of mature cathepsin B in aging rat liver 
      Keppler, Daniel; Walter, Robin; Pérez, Claudio; Sierra, Felipe (Springer Verlag, 2000)
      Senescence has been proposed as an important safeguard against neoplasia. One of the hallmarks of cellular senescence in vitro as well as human aging in vivo is a reduced intracellular protein catabolism. The pathways ...
    • T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells 
      Leiva-Salcedo, Elias; Perez, Viviana; Acuña Castillo, Claudio; Walter, Robin Ann; Sierra, Felipe (Society of Biology of Chile, 2002)
      Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
    • T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response 
      Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...