Browsing by Author "9ca89cd0-e0f9-4de7-9fe7-cf307bf495af"

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    • Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity ... 
      Castro Fernández, Víctor; Herrera Morande, Alejandra; Zamorano Sarria, Ricardo; Merino, Felipe; González Órdenes, Felipe; Padilla Salinas, Felipe; Pereira, Humberto M.; Brandao Neto, José; Garratt, Richard C.; Guixé Leguía, Victoria Cristina (American Society for Biochemistry and Molecular Biology, 2017)
      One central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cause an enzyme to change its substrate specificity; however, these processes remain largely unexplored. Using the glycolytic ...
    • The crystal complex of phosphofructokinase-2 of Escherichia coli with fructose-6-phosphate: Kinetic and ... 
      Cabrera Paucar, Ricardo; Báez, Mauricio; Pereira, Humberto M.; Caniuguir, André S.; Garratt, Richard C.; Babul Cattán, Jorge (2011)
      Substrate inhibition by ATP is a regulatory feature of the phosphofructokinases isoenzymes from Escherichia coli (Pfk-1 and Pfk-2). Under gluconeogenic conditions, the loss of this regulation in Pfk-2 causes substrate ...