Browsing by Author "9cc1eef0-3612-4f85-a5ed-259962720035"

Now showing items 1-3 of 3

    • Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network 
      Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of ... 
      Parra Ortíz, María Valentina; Bravo Sagua, Roberto; Norambuena Soto, Ignacio; Hernández Fuentes, Carolina; Gómez Contreras, Andrés; Verdejo, Hugo E.; Mellado, Rosemarie; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Elsevier, 2017)
      Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells (PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood oxygenation and cardiac work overload, which are the ...
    • Vaccines against components of the renin-angiotensin system 
      Garay Gutiérrez, Noé Francisco; Hernández Fuentes, Carolina; García Rivas, Gerardo; Lavandero González, Sergio; Guerrero Beltrán, Carlos Enrique (Springer, 2020)
      Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important ...