Browsing by Author "9e53d4b8-3402-4486-b627-0ca912310dd5"
Now showing items 1-11 of 11
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Aravena, Javier; Abrigo, Johanna; González, Francisco; Aguirre, Francisco; González, Andrea; Simon Pino, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
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Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simón, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong Lay, Mario; Cabello Verrugio, Claudio (MDPI, 2020)Skeletal muscle atrophy, which occurs in lipopolysaccharide (LPS)-induced sepsis, causes a severe muscle function reduction. The increased autophagy contributes to sepsis-induced skeletal muscle atrophy in a model of LPS ...
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Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
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Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Lippincott Williams & Wilkins, 2020)
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Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
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González, Andrea; Huerta Salgado, Camila; Orozco Aguilar, Josué; Aguirre, Francisco; Tacchi, Franco; Simón, Felipe; Cabello Verrugio, Claudio (Hindawi, 2020)Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more ...
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Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...
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González, Andrea; Orozco Aguilar, Josué; Achiardi, Óscar; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) ...
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Barrera, Francisco; Martin, Diego San; Cofre, Catalina; Solis, Nancy; Pizarro, Margarita; Cabrera, Daniel; Cabello Verrugio, Claudio; Abrigo, Johanna; Irigoyen, Betzabe; Campos Aroca, Fabian A.; Carrasco Aviño, Gonzalo; Bezares, Katiuska; Soza, Alejandro; Ben Tez, Carlos E.; Arrese, Marco (Wiley, 2017)
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Jiménez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello Verrugio, Claudio; Cerda Arancibia, Óscar; Simón, Felipe (MDPI, 2020)The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM ...
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Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...