Browsing by Author "9ee3d363-74f2-4a69-959b-bb99a7afe0cb"
Now showing items 1-11 of 11
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Lardone, M. C.; Parada-bustamante, A.; Ebensperger, M.; Valdevenito, R.; Kakarieka, E.; Martínez, D.; Pommer, R.; Piottante, A.; Castro, A. (2011)DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenital (AHC) critical region on the X chromosome gene 1; NR0B1] is an orphan nuclear receptor that acts as a transcriptional repressor in adrenal/gonadal development, ...
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Parada-Bustamante, A.; Molina, C.; Valencia, C.; Flórez, M.; Lardone, M. C.; Argandoña, F.; Piottante, A.; Ebensperguer, M.; Orihuela, P. A.; Castro, A. (Blackwell Publishing Ltd, 2017)© 2017 American Society of Andrology and European Academy of Andrology Estradiol (E2) is normally metabolized to hydroxyestradiols and methoxyestradiols by CYP1A1, CYP1B1 and COMT. However, an altered production of these ...
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Massardo Vega, Teresa; Araya, A. V.; Prat Martorell, Hernán; Alarcón, L.; Berrocal, I.; Pino, A.; Cordero, F.; Jaimovich, R.; Fernández, R.; Herrera, E.; Carmona, J.; Castro, A. (Springer, 2020)Introduction Complications from diabetes mellitus (DM) include cardiovascular system, peripheral neuropathy (PN), and autonomic dysfunction (AD). Goal: Assess the association of silent myocardial ischemia, AD, and PN in ...
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Lardone, M. C.; Argandoña, F.; Lorca, M.; Piottante, A.; Palma Ceppi, Cristian; Ebensperger, Mauricio; Castro, A.; Florez, M. (Oxford Univ. Press, 2018-04)STUDY QUESTION: Is the expression of steroidogenic enzyme 17 alpha-Hydroxylase/17,20-Lyase (CYP17A1) down-regulated in Leydig cells (LCs) of men with spermatogenic failure and compensated impairment of LC function, i.e. a ...
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Martínez, D.; Castro, A.; Merino Osorio, Paulina; López, P.; Lardone, María Cecilia; Iñíguez Vila, Germán; Cassorla Goluboff, Fernando; Codner Dujovne, Ethel (2016)AimsTo assess serum oestrogen levels and oestrogenic activity in adolescents with Type 1 diabetes compared with a healthy control group. MethodsWe conducted a cross-sectional study that evaluated adolescents with Type ...
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Lardone, M. C.; Argandoña, F.; Flórez, M.; Parada-Bustamante, A.; Ebensperger, M.; Palma, C.; Piottante, A.; Castro, A. (Blackwell Publishing Ltd, 2017)© 2016 American Society of Andrology and European Academy of Andrology Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E2) to T ratio in secretory infertile ...
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P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure Lardone, M. C.; Castillo, P.; Valdevenito, R.; Ebensperger, M.; Ronco Macchiavello, Ana María; Pommer, R.; Piottante, A.; Castro, A. (Blackwell Publishing Ltd, 2010)There is evidence that impaired spermatogenesis is associated with an imbalance in the oestradiol/testosterone ratio and with Leydig cell (LC) dysfunction. In testis, P450-aromatase, encoded by CYP19, is responsible for ...
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Larrondo, J.; Cabrera, R.; Gosch, M.; Larrondo, F.; Aylwin, M.; Castro, A. (Wiley, 2020)
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Castro, A.; Rodríguez, F.; Flórez, M.; López, P.; Curotto, B.; Martínez, D.; Maturana, A.; Lardone, M. C.; Palma, C.; Mericq, Verónica; Ebensperger, M.; Cassorla Goluboff, Fernando (Oxford University Press, 2017)© The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. STUDY QUESTION: Are copy number variations (CNVs) in the pseudoautosomal ...
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Lardone, M. C.; Parodi, D. A.; Valdevenito, R.; Ebensperger, M.; Piottante, A.; Madariaga, M.; Smith, R.; Pommer, R.; Zambrano, N.; Castro, A. (2007)Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this condition. This study investigated ...
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Hasbún, T.; Reculé, F.; Happle, R.; Zenker, M.; Schanze, D.; Castro, A. (Wiley, 2020)