Browsing by Author "XX568981"
Now showing items 1-20 of 87
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Izquierdo, S.; Kogan Bocian, Marcelo; Parella, T.; Moglioni, A. G.; Branchadell, V.; Giralt, Ernest; Ortuño, R. M. (AMER CHEMICAL SOC, 2004-07-23)The efficient synthesis of tetrapeptide 5 containing, in alternation, cyclobutane and beta-alanine residues is described. NMR experiments both at low temperature in CDCl3 and at 298 K in DMSOd(6) solutions show the ...
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Azócar, Manuel; Tamayo, Laura; Vejar, Nelson; Gómez, Grace; Zhou, Xiangrong; Thompsom, George; Cerda, Enrique; Kogan Bocian, Marcelo; Salas, Edison; Páez, Maritza (Kluwer Academic Publishers, 2014)We report here a systematic study of the antibacterial behavior of silver nanoparticles coated with fatty acids (oleic: AgNP-O, linoleic: AgNP-L, and palmitic acids: AgNP-P) in water. We have found remarkable differences ...
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Boussert, Stephanie; Díez Pérez, Ismael; Kogan Bocian, Marcelo; De Oliveira, Eliandre; Giralt, Ernest (2009)Amyloids are a family of self-aggregating proteins implicated in various central nervous system disorders, including Alzheimer's disease (AD). It is thought that prefibrillar soluble forms of amyloid peptides, including ...
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Duffau, Boris; Camargo Grandón, Rodrigo; Kogan Bocian, Marcelo; Fuentes Pérez, Edwar; Cassels Niven, Bruce (Oxford University Press, 2016)Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated ...
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Azócar, M. Ignacio; Gómez, Grace; Velásquez, Carla; Abarca, Romina; Kogan Bocian, Marcelo; Páez, Maritza (Elsevier, 2014)Antibacterial properties of silver(I)-pyridinedicarboxylate compounds (with Pyridine-2,3-dicarboxylic(Lutidinic acid), pyridine-2,4-dicarboxylic (Quinolinic acid) and pyridine-2,5-dicarboxylic (Isocinchomeronic acid)) ...
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Lasagna Reeves, C.; González Romero, D.; Barría, M. A.; Olmedo, I.; Clos, A.; Sadagopa Ramanujam, V. M.; Urayama, A.; Vergara, L.; Kogan Bocian, Marcelo; Soto, C. (ELSEVIER, 2010)Gold nanoparticles (GNPs) offer a great promise in biomedicine. Currently, there is no data available regarding the accumulation of nanoparticles in vivo after repeated administration. The purpose of the present study ...
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Molina Pelayo, Claudia Macarena (Universidad de ChileCyberDocs, 2010)A pesar de los grandes adelantos científicos y tecnológicos, hoy en día aún hay diversas enfermedades que no poseen un método de diagnóstico y/o de tratamiento temprano y efectivo. Es por ello que actualmente se está ...
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Riveros, A. L.; Astudillo, J.; Vásquez, C.; Jara, Danilo; Guerrero Hernández, Ariel; Gúzman, F.; Osorio Román, Igor; Kogan Bocian, Marcelo (Springer, 2016)Highly fluorescent nanoparticles, or quantum dots, have multiple applications in biology and biomedicine; however, in most cases, it is necessary to functionalize them to enhance their biocompatibility and selectivity. ...
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Mena, Juan F.; Neira Carrillo, Andrónico; Yazdani-Pedram Zobeiri, Mehrdad; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)With the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and ...
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de la Fuente, Elizabeth; Adura, Carolina; Kogan Bocian, Marcelo; Bollo Dragnic, Soledad (2012)The inhibition of aggregation and disaggregation effect of a β-sheet breaker was evaluated by in situ electrochemistry of the Aβ 1-42 peptide. The exposition of 10tyr residue was followed using a carbon nanotubes modified ...
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Yáñez-S, Mauricio; Matsuhiro, Betty; Maldonado, Santiago; González, Raúl; Luengo, Jorge; Uyarte, Omar; Serafine, Daniel; Moya, Sergio; Romero, Julio; Torres, Rodrigo; Kogan Bocian, Marcelo (Springer, 2018-05)The objective of the present study was to synthesize sodium carboxymethylcellulose from Eucalyptus nitens cellulose. The cellulose extraction was carried out in three stages. In the first stage, E. nitens wood was fractionated ...
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Arenas, Andrea; López Alarcón, Camilo; Kogan Bocian, Marcelo; Lissi Gervaso, Eduardo A.; Davies, Michael; Silva, Eduardo (2013)Chemical and structural alterations to lysozyme (LYSO), glucose 6-phosphate dehydrogenase (G6PD), and bovine eye lens proteins (BLP) promoted by peroxyl radicals generated by the thermal decomposition of 2,2′-azobis(2 ...
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Ruff, J.; Hassan, N.; Morales Zavala, Francisco; Steitz, J.; Araya, E.; Kogan Bocian, Marcelo; Simon, U. (Royal Soc Chemistry, 2018-04-28)Gold nanoparticles with specific optical properties in combination with the CLPFFD peptide that exhibits selectivity for beta-amyloid (A beta) aggregates are promising photothermal absorbers for application in Alzheimer's ...
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Hosta, Leticia; Pla-Roca, Mateu; Arbiol, Jordi; López Iglesias, Carmen; Samitier, Josep; Cruz, Luis; Kogan Bocian, Marcelo; Albericio, Fernando (2009)Two Cys-containing analogues of the anticancer drug Kahalalide F are synthesized and conjugated to 20 and 40 nm gold nanoparticles (GNPs). The resulting complexes are characterized by different analytical techniques to ...
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Sierpe, R.; Noyong, Michael; Simon, Ulrich; Aguayo, D.; Huerta, J.; Kogan Bocian, Marcelo; Yutronic Sáez, Nicolás (Elsevier, 2017)As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG ...
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Tamayo, Laura; Azócar, Manuel; Kogan Bocian, Marcelo; Riveros, Ana; Páez, Maritza (2016)The development of polymer nanocomposites with antimicrobial properties has been a key factor for controlling or inhibiting the growth of microorganisms and preventing foodborne diseases and nosocomial infections. Commercially ...
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Adriazola Moyano, Ricardo Ariel (Universidad de ChilePrograma Cybertesis, 2006)El Servicio Médico Legal (SML) de Santiago es una entidad pública dependiente del Ministerio de Justicia, cuya misión es asesorar a los Tribunales de Justicia y al Ministerio Público, en materias médico-legales, a través ...
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Pérez Ortiz, María Magdalena (Universidad de Chile, 2014-05)Para probar este concepto, se sintetizaron en fase sólida tres nuevos análogos del GLP-1, los cuales fueron caracterizados por cromatografía líquida y espectrometría de masas. Adicionalmente, a los péptidos se les evaluó ...
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Brain Isasi, S.; Quezada Aburto, Cristián Salvador; Pessoa Mahana, Hernán; Morello Casté, Antonio; Kogan Bocian, Marcelo; Álvarez Lueje, Alejandro (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08-15)This work presents the development of analytical methodologies by UV spectrophotometry and HPLC to characterize five nitroarylbenzimidazole derivatives with activity against Trypanosoma cruzi: NB, BNB, PNB, PMNB and PCNB. ...
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Montero Silva, Francisco; Kogan Bocian, Marcelo; Montenegro, Iván; Guzmán, Fanny; Navarrete, Soledad; Parra, Carolina; Seeger, Michael (Institution of Engineering and Technology, 2019)This work determined the potency of hexyl-ciprofloxacin molecules that reversibly interact with gold nanoparticles (AuNPs) passivated with 11-mercaptoundecanoic acid (MUA) on Escherichia coli cells. For this, partition of ...