Browsing by Author "XX569540"

Now showing items 1-20 of 26

    • A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells ... 
      Gleisner Muñoz, María Alejandra; Pereda Ramos, Cristián; Tittarelli Elaskar, Andrés; Navarrete Sánchez, Mariela; Fuentes Villegas, Camila; Ávalos, Ignacio; Tempio Sepúlveda, Fabián; Araya, Juan Pablo; Becker, María Inés; González Bergas, Fermín; López Nitsche, Mercedes; Salazar Onfray, Flavio (BMJ, 2020)
      Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of ...
    • Adenosine A(3) receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in ... 
      Torres, Angelo; Vargas, Yosselyn; Uribe, Daniel; Jaramillo, Catherine; Gleisner Muñoz, María Alejandra; Salazar Onfray, Flavio; López Nitsche, Mercedes; Melo, Rómulo; Oyarzún, Carlos; San Martín, Rody; Quezada, Claudia (Impact Journals LLC, 2016)
      MRP1 transporter correlates positively with glioma malignancy and the Multiple Drug Resistance (MDR) phenotype in Glioblastoma Multiforme (GBM). Evidence shows that the MRP1 transporter is controlled by the adenosine ...
    • Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside 
      Palacios, Miriam; Tampe, Ricardo; Campo, Miguel del; Zhong, Ta-Ying; López, Mercedes N.; Salazar Onfray, Flavio; Becker, María Inés (Elsevier, 2018-04-25)
      Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
    • Cancer vaccine design based on tumor cell lysates and adjuvants 
      Salazar Onfray, Flavio (2016)
    • The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells ... 
      Bueno, Susan; González, Pablo A.; Carreño Márquez, Leandro; Tobar, Jaime A.; Mora, Guido C.; Pereda, Cristián; Salazar Onfray, Flavio; Kalergis, Alexis M. (BLACKWELL, 2008-08)
      Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived ...
    • Caracterización de antígenos asociados a melanoma derivados del receptor melanocortina 1 (MC1R) 
      Serrano Gómez, Antonio Enrique (Universidad de Chile, 2000)
    • Chile despertó. Lecturas desde la Historia del estallido social de octubre 
      Salazar Onfray, Flavio (Universidad de Zulia, Venezuela, 2020)
    • Connexin-Mediated Signaling at the Immunological Synapse 
      Tittarelli, Andrés; Navarrete, Mariela; Gleisner, María Alejandra; Gebicke Härter, Peter; Salazar Onfray, Flavio (MDPI, 2020)
      The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation ...
    • Dendritic cell chimerism in oral mucosa of transplanted patients affected by graft-versus-host disease 
      Pérez, Claudio A.; Rabanales, Ramón; Rojas Alcayaga, Gonzalo; Larrondo Lillo, Milton; Escobar Álvarez, Alejandro; López, Mercedes N.; Salazar Onfray, Flavio; Alfaro Lucero, Jorge; González, Fermin E. (John Wiley & Sons, 2016)
      ObjectiveGraft-versus-host disease (GVHD) is one of the main complications after haematopoietic stem cell transplantation. Clinical features of GVHD include either an acute (aGVHD) or a chronic (cGVHD) condition that affects ...
    • Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells 
      Mendoza Naranjo, Ariadna; Sáez, Pablo J.; Johansson, C. Christian; Ramírez Fernández, Marcos; Mandakovic Seyler, Dinka; Pereda, Cristián; López Nitsche, Mercedes; Kiessling, Rolf; Sáez, Juan C.; Salazar Onfray, Flavio (2007)
      Previously, we found that human dendritic cells (hDCs) pulsed with a melanoma cell lysate (MCL) and stimulated with TNF-ce (MCL/TNF) acquire a mature phenotype in vitro and are able to trigger tumor-specific immune responses ...
    • Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity 
      Tittarelli, Andrés; Mendoza Naranjo, Ariadna; Farías, Marcela; Guerrero, Israel; Ihara, Fumitaka; Wennerberg, Erik; Riquelme, Sebastián; Gleisner, Alejandra; Kalergis, Alexis; Lundqvist, Andreas; López Nitsche, Mercedes; Chambers, Benedict J.; Salazar Onfray, Flavio (The American Association of Immunologists, 2014)
      Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune system, mediates Ag transfer between human dendritic cells ...
    • Heat-Shock Induction of Tumor-Derived Danger Signals Mediates Rapid Monocyte Differentiation into Clinically ... 
      Aguilera, Raquel; Saffie, Carlos; Tittarelli, Andrés; González Bergas, Fermín; Ramírez Fernández, Marcos; Reyes, Diego; Pereda, Cristián; Hevia, Daniel; García, Tamara; Salazar, Lorena; Ferreira Vigouroux, Luis Arturo; Hermoso Ramello, Marcela; Mendoza Naranjo, Ariadna; Ferrada, Carlos; Garrido, Paola; López Nitsche, Mercedes; Salazar Onfray, Flavio (AMER ASSOC CANCER RESEARCH, 2011-04-15)
      Purpose: This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen–presenting cells (TAPCells). In particular, we identified factors ...
    • High CD8(+) and absence of Foxp3(+) T lymphocytes infiltration in gallbladder tumors correlate with prolonged ... 
      Fluxá Rojas, Paula; Rojas Sepúlveda, Daniel; Gleisner, María Alejandra; Tittarelli, Andrés; Villegas, Pablo; Tapia, Loreto; Rivera, María Teresa; López Nitsche, Mercedes; Catán, Felipe; Uribe Maturana, Mario; Salazar Onfray, Flavio (BIOMED Central Ltd., 2018)
      Background: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only ...
    • Highway franchising and real estate values 
      Escobar, A.; López, M.; Serrano, A.; Ramírez, M.; Pérez, C.; Aguirre, A.; González, R.; Alfaro del Prado, Juan Ignacio; Larrondo Lillo, Milton; Fodor, Miguel; Ferrada, Carlos; Salazar Onfray, Flavio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-05)
      It has become increasingly common worldwide to auction the construction and operation of new highways to the bidder that charges the lowest toll. The resulting highway franchises often entail large increases in the value ...
    • Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 ... 
      Tittarelli, Andrés; Navarrete, Mariela; Lizana, Marcelo; Hofmann Vega, Francisca; Salazar Onfray, Flavio (MDPI, 2020)
      Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
    • Immunological considerations for developing optimal whole tumor cell-derived cancer vaccines 
      Salazar Onfray, Flavio (BMJ, 2020)
    • Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma ... 
      González Bergas, Fermín; Ramírez Fernández, Marcos; Allerbring, Eva B.; Fasching, Nina; Lundqvist, Andreas; Poschkee, Isabel; Achour, Adnane; Salazar Onfray, Flavio (Elsevier, 2013-10-12)
      Background: Melanocortin 1 Receptor (MC1R) is expressed in a majority of melanoma biopsies and cell lines. We previously demonstrated that three hydrophobic low-affinity HLA-A2-restricted MC1R-derived peptides: MC1R291–298, ...
    • Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic ... 
      González Bergas, Fermín; Ortiz, Carolina; Reyes Rojas, Montserrat; Dutzan Muñoz, Nicolás; Patel, Vyomesh; Pereda, Cristián; Gleisner Muñoz, María Alejandra; López Nitsche, Mercedes; Gutkind, J. Silvio; Salazar Onfray, Flavio (John Wiley & Sons Ltd,, 2014)
      We have previously reported a novel method for the production of tumour-antigen-presenting cells (referred to as TAPCells) that are currently being used in cancer therapy, using an allogeneic melanomaderived cell lysate ...
    • Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections 
      Gleisner, María Alejandra; Navarrete, Mariela; Hofmann, Francisca; Salazar Onfray, Flavio; Tittarelli, Andrés (Frontiers media SA, 2017)
      Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
    • Nuevas armas inmunológicas para la medicina del siglo XXI: Terapia biológica basada en el uso de anticuerpos ... 
      Aguillón Gutiérrez, Juan Carlos; Contreras L., Juan; Dotte G., Andrés; Cruzat C., Andrea; Catalán Martina, Diego; Salazar A., Lorena; Molina S., María Carmen; Guerrero P., Julia; López Nitsche, Mercedes; Soto Sáez, Lilian; Salazar Onfray, Flavio; Cuchacovich Turteltaub, Miguel (Sociedad Médica de Santiago, 2003)
      The fusion of a murine B cell and a myeloma cell generates a hybridoma that produces monoclonal antibody (mAb). These murine mAb induce the HAMA (human anti-mouse antibodies) response. Murine mAb have been modified by ...