Browsing by Author "XX578175"

Now showing items 21-29 of 29

    • Neurotoxicity of some MAO Inhibitors in Adult Rat Hypothalamic Cell Culture 
      Hurtado Guzmán, C.; Martínez Alvarado, P.; Dagnino Subiabre, A.; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Cassels Niven, Bruce; Segura Aguilar, Juan (Taylor & Francis Ltd, 2001-05-04)
      Monoamine oxidase-A (MAO-A) (amiflamine (AMF) and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHTcells derived from adult rat ...
    • On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: ... 
      Arriagada, C.; Paris Pizarro, Irmgard; Matas, M. J. S. de las; Martínez Alvarado, P.; Cárdenas, S.; Castañeda, P.; Graumann, Rebecca; Pérez Pastene, C.; Olea Azar, Claudio; Couve, E.; Herrero, M. T.; Caviedes Fernández, Pablo; Segura Aguilar, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07)
      Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 muM aminochrome with 100 muM dicoumarol, an ...
    • On the role of DT- diaphorase inhibition in aminochrome- induced neurotoxicity in vivo 
      Herrera Soto, Andrea; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Muñoz, Patricia; Henny, Pablo; Steinbusch, Harry W. M.; Segura Aguilar, Juan (Springer, 2017)
      Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. ...
    • On the role of mining exposure in epigenetic effects in parkinson’s disease 
      Castillo, Sebastián; Muñoz, Patricia; Behrens Pellegrino, María Isabel; Díaz Grez, Fernando; Segura Aguilar, Juan (Springer, 2017)
      To explore the possible influence of heavy metal mining on incidence of Parkinson’s disease (PD), global DNA methylation was assessed in blood samples from a population of PD patients (n = 45) and control subjects (n = ...
    • Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival 
      Martínez Alvarado, P.; Dagnino Subiabre, Alexies; Paris Pizarro, Irmgard; Metodiewa, D.; Welch, C. J.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (ACADEMIC PRESS INC, 2001-05-25)
      The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
    • Protective and toxic roles of dopamine in Parkinson's disease 
      Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia; Ferrari, Emanuele; Zecca, Luigi; Zucca, Fabio A. (International Society for Neurochemistry,, 2014)
      The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson’s disease are still unknown. The discovery of genes ...
    • Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity 
      Lozano, Jorge; Muñoz, Patricia; Nore, Beston F.; LeDoux, Susan; Segura Aguilar, Juan (AMER CHEMICAL SOC, 2010-09)
      DT-Diaphorase has been proposed to play a neuroprotective role in dopaminergic neurons by preventing aminochrome neurotoxicity. There are several studies supporting this idea, but in all studies, we used dicoumarol, an ...
    • The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity 
      Creusa Santos, Cleonice; Muñoz Casas del Valle, Patricia; Almeida, Áurea María A. N.; Pereira de Lima David, Juceni; Jorge Mauricio, David; Costa, Silvia Lima; Segura Aguilar, Juan; Amaral Silva, Víctor Diogenes (Springer, 2020)
      Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells ...
    • The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores ... 
      Huenchuguala Peralta, Sandro; Muñoz Tapia, Patricia; Segura Aguilar, Juan (American Chemical Society, 2017)
      Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...