Browsing by Author "XX578175"
Now showing items 1-20 of 29
-
(Bentham Science, 2016)The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...
-
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures (Elsevier, 2018-05)Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, ...
-
(SPRINGER, 2010-01-20)Abstract In previous studies, we observed that cells treated with aminochrome obtained by oxidizing dopamine with oxidizing agents dramatically changed cell morphology, thus posing the question if such morphological changes ...
-
(Springer, 2016)L-Dopa continues to be the gold drug in Parkinson's disease ( PD) treatment from 1967. The failure to translate successful results from preclinical to clinical studies can be explained by the use of preclinical models which ...
-
(Elsevier, 2017)Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now, there is no evidence that aminochrome induces glial activation ...
-
(2007)We have studied the association of a null mutation of Glutathione Transferase M1 (GST M1 *0/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the ...
-
(Elsevier, 2011-01)
-
(DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2005)Cell culture is highly desirable, as it provides systems for ready, direct access and evaluation of tissues. The use of tissue culture is a valuable tool to study problems of clinical relevance, especially those related ...
-
(Frontiers Media, 2016-04)
-
(BLACKWELL SCIENCE LTD, 2001-04)The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
-
(AMER CHEMICAL SOC, 2005-03)We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
-
(Universidad de ChilePrograma Cybertesis, 2008)
-
(Oxford University Press, 2015)It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
-
(Elsevier, 2016)Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
-
(Universidad de Chile, 2008)El objetivo de este trabajo fue demostrar que la glutatión transferasa M2-2 humana (GST M2-2), protege a los astrocitos de los efectos tóxicos del aminocromo, ya que en estudios in vitro utilizando la enzima ...
-
(Taylor & Francis inc., 2016)
-
(WILEY-LISS, 2006-11-01)We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS-related genes (App, amyloid precursor protein; Sod1, Cu/Zn superoxide dismutase) ...
-
(Springer, 2017)The Na+/myo-inositol cotransporter (SMIT1) is overexpressed in human Down syndrome (DS) and in trisomy 16 fetal mice (Ts16), an animal model of the human condition. SMIT1 overexpression determines increased levels of ...
-
(BLACKWELL PUBLISHING LTD, 2005-03)The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both ...
