Browsing by Author "XX582110"
Now showing items 1-14 of 14
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(Universidad de Chile, 2013-12)La monoamino Oxidasa A humana es una enzima que metaboliza sustratos biogénicos como los neurotransmisores 5-HT, DA, NA, TA, entre otros. Existen diversas propuestas mecanísticas para la reacción de deaminación oxidativa ...
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(American Chemical Society, 2020)The human 5-HT2 receptor subtypes have high sequence identity in their orthosteric ligand-binding domain, and many agonists are poorly selective between the S-HT(2A )and 5-HT2C subtypes. Nevertheless, their activation is ...
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(Asoc Quimicos, Inst Quimico Sarria, 2015)The photophysical behavior of 7-amino-3-phenyl-2H-benzo[b][1,4]oxazin-2-one was studied in organic solvents and in aqueous solutions of beta-cyclodextrin using steady-state fluorescence and computational chemistry methods. ...
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(Universidad de Chile, 2014)La enzima Monoamino oxidasa A (MAO-A) participa en las vías de degradación de diferentes neurotransmisores, entre ellos la serotonina, razón por la cual es punto de interés de investigadores para el desarrollo de antidepresivos ...
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(American Chemical Society, 2020)The interaction mechanism between a scarcely soluble copper(II) complex of Cu(II)-6-hydroxychromone-3carbaldehyde-(3'-hydroxy)benzoylhydrazone( CuCHz) in aqueous solution and its DM beta CD complex was studied in the ...
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Interaction of LD14 and TiO2 in dye-sensitized solar-cells (DSSC): A density functional theory study (Elsevier, 2015)The interaction and electron injection processes of the LD14 dye on TiO2 cluster (anatase phase) in dyesensitized solar cells (DSSCs) have been studied through calculations based on density functional theory (DFT) at the ...
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(Universidad de Chile, 2013)La industria biotecnológica precisa del uso de enzimas optimizadas, en particular, de termoestabiliad elevada ya que procesos industriales como la elaboración de biocombustibles de segunda generación requieren temperaturas ...
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(Universidad de Chile, 2012)Enfermedades como la sepsis, artritis reumatoide, tendinitis, entre otras, están ligadas a respuestas pro-inflamatorias anómalas. En ellas participan citoquinas pro-inflamatorias y factores de transcripción activados a ...
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(Universidad de Chile, 2012)Los receptores TLR4, participantes de la respuesta innata inmune, son capaces de reconocer patrones exógenos altamente conservados, además de otros ligandos de carácter endógeno. Dicho reconocimiento repercute en la formación ...
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Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition (2015)A MD simulation protocol was developed to model halogen bonding in protein–ligand complexes by inclusion of a charged extra point to represent the anisotropic distribution of charge on the halogen atom. This protocol ...
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Revealing Monoamine Oxidase B Catalytic Mechanisms by Means of the Quantum Chemical Cluster Approach (Amer Chemical Soc, 2015)Two of the possible catalytic mechanisms for neurotransmitter oxidative deamination by monoamine oxidase B (MAO B), namely, polar nucleophilic and hydride transfer, were addressed in order to comprehend the nature of ...
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(Royal Soc Chemistry, 2016)The inclusion complexation behavior of 3-(2-thienyl)-[1,2,3]triazolo[1,5-a]pyridine ( TTP) with native beta-cyclodextrin and derivatized cyclodextrins was investigated. Stability constants for complexes with 1 : 1 molar ...
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(Elsevier, 2015)tThe chemosensor 3-phenyl-7-(pyrid-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (PhPTP) used in combinationwith two different cyclodextrins, enable its solubilization and stabilization in aqueous solution. Thebehavior of the ...
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(Public Library Science, 2016)Despite their structural and chemical commonalities, p-chloro-beta-methylphenethylamine and p-methoxy-beta-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional ...
