Browsing by Author "XX595218"

Now showing items 1-10 of 10

    • ATP signaling in skeletal muscle: from fiber plasticity to regulation of metabolism 
      Casas Atala, Mariana; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique (2014)
      Tetanic electrical stimulation releases adenosine triphosphate (ATP) from muscle fibers through pannexin-1 channels in a frequency-dependent manner; extracellular ATP activates signals that ultimately regulate gene ...
    • Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity 
      Jorquera, Gonzalo; Altamirano, Francisco; Contreras Ferrat, Ariel Eduardo; Almarza, Gonzalo; Buvinic Radic, Sonja; Jacquemond, Vincent; Jaimovich Pérez, Enrique; Casas Atala, Mariana (The Company of Biologists, 2013)
      An important pending question in neuromuscular biology is how skeletal muscle cells decipher the stimulation pattern coming from motoneurons to define their phenotype as slow or fast twitch muscle fibers. We have previously ...
    • Changes in gene expression of the MCU complex are induced by electrical stimulation in adult skeletal muscle 
      Quezada Cornejo, Esteban; Díaz Vegas, Alexis; Jaimovich Pérez, Enrique; Casas Atala, Mariana (Frontiers Media, 2021)
      The slow calcium transient triggered by low-frequency electrical stimulation (ES) in adult muscle fibers and regulated by the extracellular ATP/IP3/IP3R pathway has been related to muscle plasticity. A regulation of muscular ...
    • Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle 
      Arias Calderón, Manuel; Almarza, Gonzalo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Valladares Ide, Denisse; Casas Atala, Mariana; Toledo Araya, Héctor; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Biomed Central, 2016)
      Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “ excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
    • Electrical Stimuli Are Anti-Apoptotic in Skeletal Muscle via Extracellular ATP. Alteration of This Signal ... 
      Valladares, Denisse; Almarza, Gonzalo; Contreras, Ariel; Pavez, Mario; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique; Casas Atala, Mariana (2013-11)
      ATP signaling has been shown to regulate gene expression in skeletal muscle and to be altered in models of muscular dystrophy. We have previously shown that in normal muscle fibers, ATP released through Pannexin1 (Panx1) ...
    • Fibroblast growth factor-21 potentiates glucose transport in skeletal muscle fibers 
      Rosales Soto, Giovanni; Díaz Vegas, Alexis; Casas Atala, Mariana; Contreras Ferrat, Ariel; Jaimovich Pérez, Enrique (Bioscientifica, 2020)
      Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism. Although ...
    • Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice 
      Campo, Andrea del; Contreras Hernández, Ignacio Alejandro; Castro Sepúlveda, Mauricio; Campos, Cristian; Figueroa, Reinaldo; Florencia Tevy, María; Eisner, Verónica; Casas Atala, Mariana; Jaimovich Pérez, Enrique (Impact Journals LLC, 2018)
      Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial ...
    • Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion 
      Mizgier, María Luisa; Casas Atala, Mariana; Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Galgani Fuentes, José (2014)
      Pancreatic beta cells sense glucose flux and release as much insulin as required in order to maintain glycaemia within a narrow range. Insulin secretion is regulated by many factors including glucose, incretins, and ...
    • Preserved Ca2+ handling and excitation-contraction coupling in muscle fibres from diet-induced obese mice 
      Jaque Fernández, Francisco; Beaulant, Agathe; Berthier, Christine; Monteiro, Laloé; Allard, Bruno; Casas Atala, Mariana; Rieusset, Jennifer; Jacquemond, Vincent (Springer, 2020)
      Aims/hypothesis Disrupted intracellular Ca2+ handling is known to play a role in diabetic cardiomyopathy but it has also been postulated to contribute to obesity- and type 2 diabetes-associated skeletal muscle dysfunction. ...
    • ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal ... 
      Díaz Vegas, Alexis; Campos, Cristian A.; Contreras Ferrat, Ariel Eduardo; Casas Atala, Mariana; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique; Espinosa Escalona, Alejandra (Public Library Science, 2015)
      During exercise, skeletal muscle produces reactive oxygen species (ROS) via NADPH oxidase (NOX2) while inducing cellular adaptations associated with contractile activity. The signals involved in this mechanism are still a ...