Now showing items 1-20 of 28

    • Tapia-Garay, Valentina; Figueroa, Daniela P.; Maldonado, Ana; Frías-Laserre, Daniel; Gonzalez, Christian R.; Parra, Alonso; Canals, Lucía; Apt Baruch, Werner; Alvarado, Sergio A.; Cáceres, Dante; Canals Lambarri, Mauricio (Fundacao Oswaldo Cruz, 2018)
      © 2018, Fundacao Oswaldo Cruz. All rights reserved. BACKGROUND Vector transmission of Trypanosoma cruzi appears to be interrupted in Chile; however, data show increasing incidence of Chagas’ disease, raising concerns that ...
    • Apt Baruch, Werner; Arribada Contreras, Julio; Zulantay Alfaro, Inés; Saavedra, Miguel; Muñoz, Catalina; Toro, Bruno; Vega, Bastián; Rodríguez Tobar, Jorge (Elsevier, 2016)
      Currently there are no biological markers to indicate which individuals with chronic indeterminate period of Chagas disease develop heart disease and who will remain all his life in this phase. The aim of this survey was ...
    • Saavedra, Miguel; Zulantay Alfaro, Inés; Apt Baruch, Werner; Martínez, Gabriela; Rojas Carrillo, Antonio; Rodríguez Borges, Jorge (2013)
      We evaluate the elimination of the microscopic stage of conventional xenodiagnosis (XD) to optimize the parasitological diagnosis of Trypanosoma cruzi in chronic Chagas disease. To this purpose we applied under informed ...
    • Apt Baruch, Werner; Zulantay Alfaro, Inés; Arnello, Marcela; Oddó, David; González, Sandra; Rodríguez Borges, Jorge; Kemmerling Weis, Ulrike; Truyens, Carine; Carlier, Yves (2013)
      Background: This study investigated the prevalence of Chagas disease (ChD) in pregnant women in Choapa Province (IV Region, Chile) and the vertical transmission of Trypanosoma cruzi. Method: ELISA and IFI IgG for ChD was ...
    • Apt Baruch, Werner; Arribada Contreras, Julio Arturo; Bulla Fernández, Daniel Héctor; Carlier, Yves; Rodrigues Coura, José; Chuit, Roberto; Pinto Dias, João Carlos; Freilij, Héctor; Gascon, Joaquim; Gómez i Prat, Jordi; Luquetti, Alejandro; Manzullo, Enrique Carlos; Márquez Córdoba, Juan Roberto; Mitelman, Jorge; Prata, Aluízio; Rassi, Anis; Reyes López, Pedro Antonio; Sosa- Estani, Sergio; Morais Torres, Rosália; Torrico, Faustino; Basmadjian Chamikian, Yester; Zackiewicz, Christina; Krishnan Karunakara, Unni; Ruiz Postigo, José Antonio; Escalante González, María del Carmen; Albajar Viñas, Pedro; Morote Castel, Sílvia; Salvatella Agrelo, Roberto (SBMT, 2005-12)
      O desenvolvimento, desde 1991, das Iniciativas Subregionais de Controle da Doença de Chagas, e os avanços de conhecimento em matéria de diagnóstico e manejo da infecção/doença de Chagas, levam a  necessidade ética, ...
    • Apt Baruch, Werner (2010)
      Chagas disease must be treated in all its stages: acute, indeterminate, chronic, and initial and middle determinant chronic, due to the fact that DNA of the parasite can be demonstrated by PCR in chronic cases, where optical ...
    • Zulantay Alfaro, Inés; Apt Baruch, Werner; Valencia, Claudio; Torres, Alberto; Saavedra, Miguel; Sánchez Rodríguez, Jorge E.; Sandoval, Lea; Martínez, Gabriela; Thieme, Patricio; Sepúlveda, Eduardo (2011)
      Objectives: This study compared three parasitological methods applied simultaneously in individuals with untreated chronic Chagas' disease in order to determine their individual and combined performances. Methods: From a ...
    • Venegas, Juan; Coñoepan, William; Pichuantes, Sergio; Miranda, Sandra; Apt Baruch, Werner; Arribada, Arturo; Zulantay Alfaro, Inés; Coronado, Ximena; Rodriguez, Jorge; Reyes, Eduardo; Solari Illescas, Aldo; Sanchez, Gittith (2009)
      PCR and Southern blot hybridization were used to determine the distribution of Trypanosoma cruzi clones in 37 chronic chagasic cardiopathic and non-cardiopathic patients. Parasite DNA amplified from peripheral blood or ...
    • Muñoz San Martín, Catalina; Zulantay Alfaro, Inés; Saavedra, Miguel; Fuentealba, Cristián; Muñoz, Gabriela; Apt Baruch, Werner (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Chagas disease is a major public health problem in Latin America and has spread to other countries due to immigration of infected persons. 10–30% of patients with chronic Chagas disease will develop ...
    • Coronado, Ximena; Zulantay Alfaro, Inés; Rozas, Marlene; Apt Baruch, Werner; Sánchez, Gittith; Rodríguez Borges, Jorge; Ortiz Zúñiga, Sylvia; Solari Illescas, Aldo (OXFORD UNIV PRESS, 2006-07)
      Objectives: The aim of this work was to study the distribution of Trypanosoma cruzi clones after treatment failure with itraconazole or allopurinol in infected humans. Methods: Blood samples from treated and untreated ...
    • Zulantay Alfaro, Inés; Apt Baruch, Werner; Ramos, Daniel; Godoy, Lorena; Valencia, Claudio; Molina, Matías; Sepúlveda, Eduardo; Thieme, Patricio; Martínez, Gabriela; Corral, Gabriela (PLOS Neglected Tropical Diseases, 2013)
    • Apt Baruch, Werner; Zulantay Alfaro, Inés (Sociedad Médica de Santiago, 2011-02)
    • Muñoz, Catalina; Zuntalay Alfaro, Inés Adriana; Apt Baruch, Werner; Ortiz Zúñiga, Sylvia; Schijman, Alejandro G.; Bisio, Margarita; Ferrada, Valentina; Herrera, Cinthya; Martínez, Gabriela; Solari Illescas, Aldo (American Society for Microbiology, 2013-09)
      Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas ...
    • Venegas Hermosilla, Juan; Miranda, Sandra; Coñoepan, William; Pîchuantes, Sergio; Jercic, María Isabel; González, Christian; Gajardo, Marta; Apt Baruch, Werner; Arribada, Arturo; Sánchez, Gittith (SPRINGER, 2010-09)
      To investigate whether Trypanosoma cruzi populations found in chagasic cardiopathic and non-cardiopathic patients are genetically differentiated, three molecular microsatellite markers were analysed. This analysis was also ...
    • Venegas, Juan; Miranda, Sandra; Coñoepan, William; Pîchuantes, Sergio; Jercic, María Isabel; González, Christian; Gajardo, Marta; Apt Baruch, Werner; Arribada, Arturo; Sánchez, Gittith (2010)
      To investigate whether Trypanosoma cruzi populations found in chagasic cardiopathic and non-cardiopathic patients are genetically differentiated, three molecular microsatellite markers were analysed. This analysis was also ...
    • Ortíz, Sylvia; Zulantay Alfaro, Inés; Solari Illescas, Aldo; Bisio, Margarita; Schijman, Alejandro; Carlier, Yves; Apt Baruch, Werner (2012)
      The objective of this study was to determine the presence of Trypanosoma cruzi in blood samples of mothers with chronic Chagas disease and their newborn by conventional PCR targeted to minicircle kinetoplastidic DNA (kDNA), ...
    • Saavedra, Miguel; Zulantay Alfaro, Inés; Apt Baruch, Werner; Castillo, Juan; Araya, Eduardo; Martínez, Gabriela; Sánchez Rodríguez, Jorge E. (BioMed Central Ltd., 2016)
      © 2016 The Author(s).Background: Trypanosoma cruzi multiplies and differentiates in the digestive tract of triatomine insects. Xenodiagnosis (XD) is a parasitological tool in which the insect vectors acts as a biological ...
    • Bravo, Nicolás; Mũoz, Catalina; Nazal, Nicolás; Saavedra, Miguel; Martínez, Gabriela; Acha Araya, Eduardo Javier; Apt Baruch, Werner; Zulantay Alfaro, Inés (2012)
      Background: The polymerase chain reaction (PCR) has proved to be a sensitive technique to detect Trypanosoma cruzi in the chronic phase of Chagas disease, which is characterized by low and fluctuating parasitemia. Another ...
    • Muñoz San Martín, Catalina; Apt Baruch, Werner; Zulantay Alfaro, Inés (Elsevier B.V., 2017)
      © 2017 Elsevier B.V. The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a major public health problem in Latin America. This parasite has a complex population structure comprised by six or seven major ...
    • Weitzel, Thomas; Zulantay Alfaro, Inés; Danquah, Ina; Hamann, Lutz; Schumann, Ralf R.; Apt Baruch, Werner; Mockenhaupt, Frank P. (2012)
      Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic ...