Now showing items 1-11 of 11

    • Díaz, Martha Lucía; Leal, Sandra; Mantilla, Julio César; Molina Berríos, Alfredo Enrique; López Muñoz, Rodrigo; Solari Illescas, Aldo; Escobar, Patricia; González Rugeles, Clara Isabel (BioMed Central, 2015)
      Background: Outbreaks of acute Chagas disease associated with oral transmission are easily detected nowadays with trained health personnel in areas of low endemicity, or in which the vector transmission has been interrupted. ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Leiva, Mario; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Elsevier, 2013)
      Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
    • Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Maya Arango, Juan (AMER SOC MICROBIOLOGY, 2008-05)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Mueller Sepúlveda, Andrea; Cid Chevecich, Camila; Jara, José A.; Belmar Pantelis, Carolina; Sandoval, Pablo; Santander Meyer, Rocío; Quijada, Raúl; Moura, Sidnei; López Muñoz, Rodrigo; Díaz Dosque, Mario; Molina Berríos, Alfredo (Georg Thieme Verlag Kg, 2020)
      Candida albicans is the most common human fungal pathogen, and with the increase in resistance rates worldwide, it is necessary to search for new pharmacological alternatives. Lavandula dentata L. essential oil is recognized ...
    • Aguilera, Benjamín; Olea Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal Emaldía, Fernando; Lapier, Michel; Maya Arango, Juan; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo (PERGAMON-ELSEVIER SCIENCE LTD, 2011-03)
      Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO ...
    • López Muñoz, Rodrigo; Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Abarca-Sanhueza, Patricio; Urrutia-Llancaqueo, Luis; Peña-Espinoza, Miguel; Maya Arango, Juan (Frontiers Media S.A., 2018)
      © 2018 López-Muñoz, Molina-Berríos, Campos-Estrada, Abarca-Sanhueza, Urrutia-Llancaqueo, Peña-Espinoza and Maya. Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp.) are protozoan parasites ...
    • Cortés, Leonel A.; Castro, Lorena; Pesce Reyes, Bárbara; Maya Arango, Juan; Ferreira, Jorge; Castro Castillo, Vicente; Parra, Eduardo; Jara, José A.; López Muñoz, Rodrigo (Public Library Science, 2015)
      Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Ferreira, Jorge; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Springer, 2013)
      Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
    • Rojo, Gemma; Castillo, Christian; Duaso, Juan; Liempi, Ana; Droguett Ossa, Daniel; Galanti Garrone, Norbel; Maya Arango, Juan; López Muñoz, Rodrigo; Kemmerling Weis, Ulrike (Elsevier, 2014)
      Nifurtimox (Nfx) and Benznidazole (Bnz) are the only available drugs in use for the treatment of Chagas disease. These drugs are recommended but not fully validated in evidence-based medicine and reports about the ...
    • López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello Casté, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...