Browsing by Author "XX602342"

Now showing items 1-10 of 10

    • Acute chagas outbreaks: molecular and biological features of Trypanosoma cruzi isolates, and clinical aspects ... 
      Díaz, Martha Lucía; Leal, Sandra; Mantilla, Julio César; Molina Berríos, Alfredo Enrique; López Muñoz, Rodrigo; Solari Illescas, Aldo; Escobar, Patricia; González Rugeles, Clara Isabel (BioMed Central, 2015)
      Background: Outbreaks of acute Chagas disease associated with oral transmission are easily detected nowadays with trained health personnel in areas of low endemicity, or in which the vector transmission has been interrupted. ...
    • Aumento de la capacidad tripanocida de nifurtimox y benznidazol a través de la inhibición de la síntesis ... 
      López Muñoz, Rodrigo (Universidad de ChileCyberDocs, 2010)
    • Benznidazole prevents endothelial damage in an experimental model of Chagas disease 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Leiva, Mario; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Elsevier, 2013)
      Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
    • Chemical Characterization of Lavandula dentata Essential Oil Cultivated in Chile and Its Antibiofilm Effect ... 
      Mueller Sepúlveda, Andrea; Cid Chevecich, Camila; Jara, José A.; Belmar Pantelis, Carolina; Sandoval, Pablo; Santander Meyer, Rocío; Quijada, Raúl; Moura, Sidnei; López Muñoz, Rodrigo; Díaz Dosque, Mario; Molina Berríos, Alfredo (Georg Thieme Verlag Kg, 2020)
      Candida albicans is the most common human fungal pathogen, and with the increase in resistance rates worldwide, it is necessary to search for new pharmacological alternatives. Lavandula dentata L. essential oil is recognized ...
    • ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted ... 
      Aguilera, Benjamín; Olea Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal Emaldía, Fernando; Lapier, Michel; Maya Arango, Juan; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo (PERGAMON-ELSEVIER SCIENCE LTD, 2011-03)
      Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO ...
    • Inflammatory and pro-resolving lipids in trypanosomatid infections: A key to understanding parasite control 
      López Muñoz, Rodrigo; Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Abarca-Sanhueza, Patricio; Urrutia-Llancaqueo, Luis; Peña-Espinoza, Miguel; Maya Arango, Juan (Frontiers Media S.A., 2018)
      © 2018 López-Muñoz, Molina-Berríos, Campos-Estrada, Abarca-Sanhueza, Urrutia-Llancaqueo, Peña-Espinoza and Maya. Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp.) are protozoan parasites ...
    • Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity 
      Cortés, Leonel A.; Castro, Lorena; Pesce Reyes, Bárbara; Maya Arango, Juan; Ferreira, Jorge; Castro Castillo, Vicente; Parra, Eduardo; Jara, José A.; López Muñoz, Rodrigo (Public Library Science, 2015)
      Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
    • Protection of vascular endothelium by aspirin in a murine model of chronic Chagas’ dise 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Ferreira, Jorge; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Springer, 2013)
      Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
    • Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human ... 
      Rojo, Gemma; Castillo, Christian; Duaso, Juan; Liempi, Ana; Droguett Ossa, Daniel; Galanti Garrone, Norbel; Maya Arango, Juan; López Muñoz, Rodrigo; Kemmerling Weis, Ulrike (Elsevier, 2014)
      Nifurtimox (Nfx) and Benznidazole (Bnz) are the only available drugs in use for the treatment of Chagas disease. These drugs are recommended but not fully validated in evidence-based medicine and reports about the ...
    • Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole 
      López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello Casté, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...