Browsing by Author "XX608965"

Now showing items 1-14 of 14

    • The Cancer-Related Transcription Factor Runx2 Modulates Cell Proliferation in Human Osteosarcoma Cell Lines 
      Lucero, Claudia M. J.; Vega, Oscar A.; Osorio, Mariana M.; Tapia Pineda, Julio; Antonelli Anativia, Juan; Stein, Gary S.; Van Wijnen, Andre J.; Galindo, Mario A. (Wiley Periodicals, 2013)
      Runx2 regulates osteogenic differentiation and bone formation, but also suppresses pre-osteoblast proliferation by affecting cell cycle progression in the G1 phase. The growth suppressive potential of Runx2 is normally ...
    • Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer ... 
      Tapia Pineda, Julio; Torres Gómez, Vicente; Rodríguez, D. A.; Leyton Campos, Lisette; Quest, Andrew F. G. (NATL ACAD SCIENCES, 2006-10-10)
      Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
    • Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis ... 
      Torres Gómez, Vicente; Tapia Pineda, Julio; Rodríguez, Diego A.; Leyton Campos, Lisette; Párraga, Mario; Lisboa, Pamela; Montoya, Margarita; Quest, Andrew F. G. (COMPANY OF BIOLOGISTS LTD, 2006-05-01)
      Caveolin-1 is suggested to act as a tumor suppressor. We tested the hypothesis that caveolin-1 does so by repression of survivin, an Inhibitor of apoptosis protein that regulates cell-cycle progression as well as apoptosis ...
    • Endothelin-1 induces changes in the expression levels of steroidogenic enzymes and increases androgen ... 
      Torres Torres, María José; López Moncada, Fernanda; Herrera, Daniela; Indo Cofré, Sebastián; Lefian, Alejandro; Llanos Vidal, Paola; Tapia Pineda, Julio; Castellón Vera, Enrique; Contreras Muñoz, Héctor (Spandidos, 2021)
      Endothelin-1 (ET-1) is involved in the regulation of steroidogenesis. Additionally, patients with castration-resistant prostate cancer (PCa) have a higher ET-1 plasma concentration than those with localized PCa and healthy ...
    • Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-kappa B ... 
      Carrillo Beltrán, Diego; Muñoz, Juan P.; Guerrero Vásquez, Nahir; Blanco, Rancés; León, Oscár; de Souza Lino, Vanesca; Tapia Pineda, Julio; Maldonado Maldonado, Edio; Dubois Camacho, Karen; Hermoso Ramello, Marcela; Coravlán, Alejandro H.; Calaf, Gloria M.; Boccardo, Enrique; Aguayo González, Francisco (MDPI, 2020)
      A subset of oral carcinomas is etiologically related to high-risk human papillomavirus (HR-HPV) infection, with HPV16 being the most frequent HR-HPV type found in these carcinomas. The oncogenic role of HR-HPV is strongly ...
    • Identification of novel variations in microRNAs genes as familial breast cancer susceptibility variants in ... 
      Landeros, Natalia; Tapia Pineda, Julio; González Hormazábal, Patricio; Jara Sosa, Lilian (Spandidos Publications Ltd., 2017)
    • In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma ... 
      Varas Godoy, Manuel; Lladser, Álvaro; Farfan, Nicole; Villota, Claudio; Villegas, Jaime; Tapia Pineda, Julio; Burzio, Luis O.; Burzio, Verónica A.; Valenzuela, Pablo D. T. (Wiley, 2018)
      The family of non-coding mitochondrial RNAs (ncmtRNA) is differentially expressed according to proliferative status. Normal proliferating cells express sense (SncmtRNA) and antisense ncmtRNAs (ASncmtRNAs), whereas tumor ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v ... 
      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...
    • Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness ... 
      Pérez Moreno, Pablo; Quezada Meza, Camila; Chávez Almarza, Cristopher; Niechi, Ignacio; Silva Pavez, Eduardo; Trigo Hidalgo, César; Aguayo González, Francisco; Jara Sosa, Lilian; Cáceres Verschae, Albano; Varas Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Verónica A.; Tapia Pineda, Julio (Frontiers Media, 2020)
      Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ...
    • Protein kinase CK2 in cancer energetics 
      Silva Pavez, Eduardo; Tapia Pineda, Julio (Frontiers Media, 2020)
      Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...
    • Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy 
      Campos, Tania; Ziehe, Javiera; Palma, Mario; Escobar, David; Tapia Pineda, Julio; Pincheira, Roxana; Castro, Ariel F. (Wiley and Sons, 2016)
      We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the Rheb/p27 axis in cancer ...
    • Transactivation activity and nucleocytoplasmic transport of β-catenin are independently regulated by its ... 
      Maturana, J.; Niechi, I.; Silva, E.; Huerta, H.; Cataldo, R.; Härtel, Steffen; Barros, L.; Galindo Díaz, Mario; Tapia Pineda, Julio (Elsevier, 2015)
      The key protein in the canonicalWnt pathway is β-catenin, which is phosphorylated both in absence and presence ofWnt signals by different kinases. Upon activation in the cytoplasm, β-catenin can enter into the nucleus ...
    • Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells 
      Carrillo, Diego; Muñoz, Juan P.; Huerta, Hernán; Leal, Gabriel; Corvalán, Alejandro; León Decap, Óscar; Calaf, Gloria M.; Urzúa Tobar, Ulises; Boccardo, Enrique; Tapia Pineda, Julio; Aguayo González, Francisco (Royal Soc., 2017)
      The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV ...
    • Wnt/β catenin signaling activates expression of the bone-related transcription factor RUNX2 in select human ... 
      Vega, Oscar A.; Lucero, Claudia M. J.; Araya, Héctor F.; Jerez, Sofía; Tapia Pineda, Julio; Antonelli Anativia, Juan; Salazar Onfray, Flavio; Heras Aliciardi, Facundo las; Thaler, Roman; Riester, Scott M.; Stein, Gary S.; van Wijnen, Andre J.; Galindo Díaz, Mario (Wiley, 2017)
      Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis and poor responsiveness to chemotherapy in osteosarcoma correlates with over-expression of the runt-related transcription factor ...