Browsing by Author "XX616126"

Now showing items 1-14 of 14

    • Aldosterone- and testosterone-mediated intracellular calcium response in skeletal muscle cell cultures 
      Estrada Hormazábal, Manuel; Liberona Leppe, José; Miranda, Manuel; Jaimovich Pérez, Enrique (Amer Physiological Soc, 2000)
      Fast nongenomic steroid actions in several cell types seem to be mediated by second messengers such as intracellular calcium ([Ca2+](i)) and inositol 1,4,5-trisphosphate (IP3). We have shown the presence of both slow calcium ...
    • Androgen-regulated cardiac metabolism in aging men 
      Barrientos Briones, Genaro; Llanos Vidal, Paola; Basualto-Alarcón, Carla; Estrada Hormazábal, Manuel (Frontiers Media, 2020)
      The prevalence of cardiovascular mortality is higher in men than in age-matched premenopausal women. Gender differences are linked to circulating sex-related steroid hormone levels and their cardio-specific actions, which ...
    • Ca2+/ Calmodulin dependent protein kinase II and androgen signaling pathways modulate MEF2 activity in ... 
      Durán, Javier; Lagos, Daniel; Pavez, Mario; Troncoso, Mayarling F.; Ramos, Sebastián; Barrientos Briones, Genaro; Ibarra, Cristián; Lavandero González, Sergio; Estrada Hormazábal, Manuel (Frontiers media SA, 2017)
      Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...
    • Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to inositol trisphosphate receptors 
      Estrada Hormazábal, Manuel; Cárdenas Matus, Julio; Liberona Leppe, José; Carrasco, María Angélica; Mignery, Gregory A.; Allen, Paul D.; Jaimovich Pérez, Enrique (Amer Soc Biochemistry Molecular Biology, 2001)
      Potassium depolarization of skeletal myotubes evokes slow calcium waves that are unrelated to contraction and involve the cell nucleus (Jaimovich, E., Reyes, R., Liberona, J. L., and Powell, J. A. (2000) Am. J. Physiol. ...
    • Dihydropyridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal ... 
      Araya, Roberto; Liberona Leppe, José; Cárdenas Matus, Julio; Riveros Keller, Nora; Estrada Hormazábal, Manuel; Powell, Jeanne A.; Carrasco, María Angélica; Jaimovich Pérez, Enrique (Rockefeller University Press, 2003)
      The dihydropyridine receptor (DHPR), normally a voltage-dependent calcium channel, functions in skeletal muscle essentially as a voltage sensor, triggering intracellular calcium release for excitation-contraction coupling. ...
    • Efecto de la testosterona en la captación de glucosa dependiente del transportador GLUT4 a través del eje ... 
      Wilson Rodríguez, Carlos Antonio (Universidad de Chile, 2011)
      La testosterona es la principal hormona sexual masculina, responsable de múltiples efectos en el organismo. Dentro de estos, se ha descrito que es capaz de producir hipertrofia cardiaca tanto in vitro como in vivo. Una ...
    • GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy 
      Durán, Javier; Oyarce Díaz, César; Pavez Giani, Mario; Valladares, Denisse; Basualto Alarcón, Carla; Lagos, Daniel; Barrientos Briones, Genaro; Troncoso Magñin, Mayarling; Ibarra, Cristián; Estrada Hormazábal, Manuel; Basualto Alarcón, Carla (Public Library Science, 2016-12-15)
      Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...
    • IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells 
      Espinosa, Alejandra; Estrada Hormazábal, Manuel; Jaimovich Pérez, Enrique (SOC ENDOCRINOLOGY, 2004-08)
      We studied the effect of IGF-I and insulin on intracellular Ca2+ in primary cultured myotubes. IGF-I induced a fast and transient Ca2+ increase, measured as fluo-3 fluorescence. This response was blocked by both genistein ...
    • Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and ... 
      Ibarra, Cristián; Estrada Hormazábal, Manuel; Carrasco Mujica, Loreto; Chiong Lay, Mario; Liberona Leppe, José; Cárdenas, César; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Amer Biochemistry Molecular Biology, 2004-02-27)
      In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca-i(2+) levels apparent both in the nucleus ...
    • Participación de la vía GSK3-[beta]/NFAT en la hipertrofia inducida por testosterona del cardiomiocito de ... 
      Oyarce Díaz, César Israel (Universidad de ChileCyberDocs, 2011)
      El uso de elevadas dosis de testosterona produce hipertrofia cardiaca, sin embargo los mecanismos celulares no son completamente entendidos. La proteína quinasa GSK3-β (glycogen synthase kinase 3-β) es una quinasa que ...
    • Regulation of Cardiovascular Metabolism by Hormones and Growth Factors 
      Ibarra, Cristián; Lavandero González, Sergio; Estrada Hormazábal, Manuel (Hindawi Pub., 2015)
    • Testosterona estimula la actividad del PPARß en cardiomiocitos de rata neonata 
      Silva Andrades, Patricio Abel (Universidad de ChileCyberDocs, 2011)
      La testosterona, a través de aumentos del Ca2+ intracelular mediado por el receptor para inositol 1,4,5 trifosfato (IP3R), produce hipertrofia del cardiomiocito. La hipertrofia conlleva un cambio metabólico que se asocia ...
    • Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes 
      Vicencio, José Miguel; Ibarra, Cristián; Estrada Hormazábal, Manuel; Chiong Lay, Mario; Soto, Dagoberto; Parra, Valentina; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (ENDOCRINE SOC, 2006-03)
      Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. These responses involve the intracellular androgen receptor. However, the mechanisms of how androgens activate several membrane ...
    • Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated ... 
      Jaimovich Pérez, Enrique; Mattei, César; Liberona Leppe, José; Cárdenas, César; Estrada Hormazábal, Manuel; Barbier, Julien; Debitus, Cécile; Laurent, Dominique; Molgó, Jordi (ELSEVIER SCIENCE BV, 2005-04-11)
      Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ ...