Now showing items 1-15 of 15

    • Tapia Pineda, Julio; Torres Gómez, Vicente; Rodríguez, D. A.; Leyton Campos, Lisette; Quest, Andrew F. G. (NATL ACAD SCIENCES, 2006-10-10)
      Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
    • Torres Gómez, Vicente; Tapia Pineda, Julio; Rodríguez, Diego A.; Leyton Campos, Lisette; Párraga, Mario; Lisboa, Pamela; Montoya, Margarita; Quest, Andrew F. G. (COMPANY OF BIOLOGISTS LTD, 2006-05-01)
      Caveolin-1 is suggested to act as a tumor suppressor. We tested the hypothesis that caveolin-1 does so by repression of survivin, an Inhibitor of apoptosis protein that regulates cell-cycle progression as well as apoptosis ...
    • Urra, Hery; Torres Gómez, Vicente; Ortiz, Rina J.; Lobos, Lorena; Díaz, María I.; Díaz, Natalia; Härtel, Steffen; Leyton Campos, Lisette; Quest, Andrew F. G. (PUBLIC LIBRARY SCIENCE, 2012-04-10)
      Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential ...
    • Rodríguez, Diego A.; Tapia, Julio; Fernández, Jaime G.; Torres Gómez, Vicente; Muñoz, Nicolás; Galleguillos, Daniela; Leyton Campos, Lisette; Quest, Andrew F. G. (2009)
      Augmented expression of cyclooxygenase-2 (COX-2) and enhanced production of prostaglandin E2 (PGE2) are associated with increased tumor cell survival and malignancy. Caveolin-1 is a scaffold protein that has been proposed ...
    • Villena, Joan; Henríquez Luna, Mauricio; Torres Gómez, Vicente; Moraga, Francisco; Díaz Elizondo, Jessica; Arredondo, Cristian; Chiong Lay, Mario; Olea Azar, Claudio; Stutzin Schottlander, Andrés; Lavandero González, Sergio; Quest, Andrew F. G. (ELSEVIER SCIENCE INC, 2008-03-15)
      In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form of cell death is linked to delayed production of endogenous ceramide and is mimicked by exogenous administration of long- and ...
    • Ortiz, Rina; Díaz Jara, Jorge; Díaz, Natalia; Lobos González, Lorena; Cárdenas, Areli; Contreras, Pamela; Díaz, María Inés; Otte, Ellen; Cooper- White, Justin; Torres Gómez, Vicente; Leyton Campos, Lisette; Quest, Andrew F. G. (Impact Journals LLC, 2016)
      Caveolin-1 (CAV1) is a scaffolding protein that plays a dual role in cancer. In advanced stages of this disease, CAV1 expression in tumor cells is associated with enhanced metastatic potential, while, at earlier stages, ...
    • Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Silva, Patricio; Venegas, Sebastián; Criollo Céspedes, Alfredo; Torres Gómez, Vicente (Wiley, 2020)
      Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
    • Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Maturana Ramírez, Andrea; Torres Gómez, Vicente (Elsevier, 2019)
      Objectives: To evaluate the localization of β-catenin in oral dysplastic cells, the expression of target genes upregulated in oral dysplasia, and the role of Wnt ligands in these events. Materials and methods: Subcellular ...
    • Peña Oyarzún, Daniel; Rodríguez Peña, Marcelo; Burgos Bravo, Francesca; Vergara, Ángelo; Kretschmar Montecinos, Catalina; Sotomayor Flores, Cristián; Ramírez Sarmiento, César A.; De Smedt, Humbert; Reyes Rojas, Montserrat; Pérez, William; Torres Gómez, Vicente; Morselli, Eugenia; Altamirano, Francisco; Wilson, Christian; Hill, Joseph A.; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Taylor & Francis, 2020)
      Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a ...
    • Torres Gómez, Vicente; Herane Herane, María Isabel; Costa, Adilson; Piquero, Martín Jaime; Troielli, Patricia (Sociedade Brasileira de Dermatologia, 2017)
      Skin disease occur worldwide, affecting people of all nationalities and all skin types. These diseases may have a genetic component and may manifest differently in specific population groups; however, there has been little ...
    • Peña Oyarzún, Daniel; Reyes Rojas, Montserrat; Hernández Cáceres, María Paz; Kretschmar, Catalina; Morselli, Eugenia; Ramírez Sarmiento, César; Lavandero González, Sergio; Torres Gómez, Vicente; Criollo, Alfredo (Frontiers Media, 2020)
      Oral squamous cell carcinoma, the most common type of oral cancer, affects more than 275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as most patients die after 3 to 5 years post-diagnosis. ...
    • Díaz Valdivia, Natalia; Díaz, Jorge; Contreras, Pamela; Campos, América; Rojas Celis, Victoria; Burgos Ravanal, Renato; Lobos González, Lorena; Torres Gómez, Vicente; Pérez, Viviana I.; Frei, Balz; Leyton Campos, Lisette; Quest, Andrew F. G. (Nature, 2020)
      Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes beta-catenin, ...
    • Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
    • Torres, Pedro; Díaz Jara, Jorge; Arce, Maximiliano; Silva, Patricio; Mendoza, Pablo; Lois, Pablo; Molina Berríos, Alfredo Enrique; Owen, Gareth I.; Palma Alvarado, Verónica; Torres Gómez, Vicente (Federation of American Societies for Experimental Biology, 2017)
      Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins. ...
    • Reyes Rojas, Montserrat; Flores Lillo, Tania; Betancur, Diego; Peña Oyarzún, Daniel; Torres Gómez, Vicente (MDPI, 2020)
      Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair and defective cell death. At the ...