A cell line (RCMH) in permanent culture was established from surgically removed adult normal human skeletal muscle by exposure to conditioned media obtained from thyroid cells. Cells proliferated indefinitely but displayed ...

In cyclosporine-based protocols, everolimus is more effective than azathioprine to reduce acute rejection. Ketoconazole may reduce cyclosporine and everolimus requirements. We compared kidney transplant patients treated ...

Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...

Depolarization of skeletal muscle cells triggers intracellular calcium signals mediated by ryanodine and IP3 receptors. We have reported that K+-induced depolarization activates the transcriptional regulators ERKs, CREB, ...

1 The action of the main ciguatoxin involved in ciguatera fish poisoning in the Pacific region (PCTX-1b) was studied in myotubes originated from rat skeletal muscle cells kept in primary culture. 2 The effect of P-CTX-1b ...

Nuclear calcium appears to have an important role in the regulation of gene expression in many cells, but the mechanisms involved in controlling nuclear Ca2+ signaling are controversial and still poorly understood. We have ...