Browsing by Author "XX644389"

Now showing items 1-16 of 16

    • Androgen-regulated cardiac metabolism in aging men 
      Barrientos Briones, Genaro; Llanos Vidal, Paola; Basualto-Alarcón, Carla; Estrada Hormazábal, Manuel (Frontiers Media, 2020)
      The prevalence of cardiovascular mortality is higher in men than in age-matched premenopausal women. Gender differences are linked to circulating sex-related steroid hormone levels and their cardio-specific actions, which ...
    • Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected ... 
      Valenzuela Báez, Rodrigo; Espinosa Escalona, Alejandra; Llanos Vidal, Paola; Hernández Rodas, María Catalina; Barrera Ramírez, Cynthia; Vergara, Daniela; Romero Palacios, Nalda; Pérez, Francisco; Ruz Ortiz, Manuel; Videla Cabrera, Luis (Royal Soc Chemistry, 2016)
      Non-alcoholic fatty liver disease (NAFLD) is characterized by liver steatosis, oxidative stress, and drastic depletion of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), namely, eicosapentaenoic acid (C20:5 n-3, ...
    • Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces ... 
      Barrientos Briones, Genaro; Llanos Vidal, Paola; Hidalgo Tapia, Jorge; Bolaños, Pura; Caputo, Carlo; Riquelme, Alexander; Sánchez, Gina; Quest, Andrew F. G.; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2015)
      Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express ...
    • Endothelin-1 induces changes in the expression levels of steroidogenic enzymes and increases androgen ... 
      Torres Torres, María José; López Moncada, Fernanda; Herrera, Daniela; Indo Cofré, Sebastián; Lefian, Alejandro; Llanos Vidal, Paola; Tapia Pineda, Julio; Castellón Vera, Enrique; Contreras Muñoz, Héctor (Spandidos, 2021)
      Endothelin-1 (ET-1) is involved in the regulation of steroidogenesis. Additionally, patients with castration-resistant prostate cancer (PCa) have a higher ET-1 plasma concentration than those with localized PCa and healthy ...
    • Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ... 
      Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Barrientos Briones, Genaro; Valencia, Marco; Mears, David; Hidalgo Tapia, María Cecilia (Public Library Science, 2015)
      Glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells requires an increase in intracellular free Ca2+ concentration ([Ca2+]). Glucose uptake into beta-cells promotes Ca2+ influx and reactive oxygen species ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ... 
      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation 
      Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Vásquez, César; Espinosa, Alejandra; Osorio Fuentealba, César; Arias Calderón, Manuel; Lavandero González, Sergio; Klip, Amira; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (The Company of Biologists Ltd, 2014)
      Insulin signaling includes generation of low levels of H2O2; however, its origin and contribution to insulin-stimulated glucose transport are unknown. We tested the impact of H2O2 on insulin-dependent glucose transport ...
    • Loss of caveolin-1 is associated with a decrease in beta cell death in mice on a high fat diet 
      Lillo Urzúa, Paloma; Núñez Murillo, Olinda; Castro Sepúlveda, Mauricio; Torres Quintana, María Angélica; Lladser Caldera, Álvaro; Quest, Andrew F. G.; Espinoza Robles, Carolina; Llanos Vidal, Paola; Wehinger, Sergio (MDPI, 2020)
      Elevated free fatty acids (FFAs) impair beta cell function and reduce beta cell mass as a consequence of the lipotoxicity that occurs in type 2 diabetes (T2D). We previously reported that the membrane protein caveolin-1 ...
    • Mitochondrial calcium increase induced by RyR1 and IP3R channel activation after membrane depolarization ... 
      Díaz Vegas, Alexis; Córdova, A.; Valladares, Denisse; Llanos Vidal, Paola; Hidalgo, C.; Gherardi, Gaia; Stefani, Diego De; Mammucari, Cristina; Rizzuto, Rosario; Contreras Ferrat, Ariel Eduardo; Jaimovich Pérez, Enrique (Frontiers Media, 2018-06)
      Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by ...
    • Neuronal and muscular alterations caused by two wheat endosperm proteins, puroindoline-a and alpha1-purothionin, ... 
      Llanos Vidal, Paola; Henríquez Luna, Mauricio; Minic, Jasmina; Elmorjani, Khalil; Marion, Didier; Riquelme Pino, Gloria; Molgó, Jordi; Benoit, Evelyne (SPRINGER, 2004-05)
      Using the patch-clamp technique it was found that the toxicity of the two wheat endosperm proteins puroindoline-a and alpha1-purothionin probably results from the dissipation of ion concentration gradients essential ...
    • NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout 
      Henríquez Olguín, Carlos; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos Acevedo, Cristian; Arias Calderón, Manuel; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Jaimovich Pérez, Enrique; Valladares Ide, Denisse (Frontiers Media, 2016)
      Reactive oxygen species (ROS) participate as signaling molecules in response to exercise in skeletal muscle. However, the source of ROS and the molecular mechanisms involved in these phenomena are still not completely ...
    • Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion 
      Mizgier, María Luisa; Casas Atala, Mariana; Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Galgani Fuentes, José (2014)
      Pancreatic beta cells sense glucose flux and release as much insulin as required in order to maintain glycaemia within a narrow range. Insulin secretion is regulated by many factors including glucose, incretins, and ...
    • Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine 
      Ronjat, Michel; Finkelstein, José Pablo; Llanos Vidal, Paola; Montecinos, Luis; Bichraoui, Hicham; Waard, Michel De; Hidalgo Tapia, María Cecilia; Bull Simpfendorfer, Ricardo (Elsevier, 2013)
      The scorpion toxin maurocalcine acts as a high affinity agonist of the type-1 ryanodine receptor expressed in skeletal muscle. Here, we investigated the effects of the reducing agent dithiothreitol or the oxidizing reagent ...
    • Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA ... 
      Valenzuela Báez, Rodrigo; Barrera Ramírez, Cynthia; Espinosa, Alejandra; Llanos Vidal, Paola; Orellana, Paula; Videla Cabrera, Luis (Elsevier, 2015)
      alpha-Linolenic (ALA) and linoleic (LA) acids are precursors of long chain polyunsaturated fatty acids (LCPUFAs), FAs with important biochemical and physiological functions. In this process, desaturation reactions catalyzed ...
    • The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic ... 
      Carrasco Pozo, Catalina; Tan, Kah Ni; Reyes Farías, Marjorie; De la Jara, Nicole; Ngo, Shyuan Thieu; García Díaz, Diego; Llanos Vidal, Paola; Cires, María José; Borges, Karin (Elsevier, 2016)
      Studying rats fed high cholesterol diet and a pancreatic beta-cell line (Min6), we aimed to determine the mechanisms by which quercetin protects against cholesterol-induced pancreatic beta-cell dysfunction and impairments ...
    • The underlying mechanisms of diabetic myopathy 
      Hernández Ochoa, Erick O.; Llanos Vidal, Paola; Lanner, Johanna T. (Hindawi Ltd., 2017)