Browsing by Author "XX676318"

Now showing items 1-20 of 27

    • Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional ... 
      Ciudad, María Teresa; Sorvillo, Nicoletta; van Alphen, Floris; Catalán Martina, Diego; Meijer, Alexander; Voorberg, Jan; Jaraquemada, Dolores (Wiley, 2017)
      Dendritic cells (DCs) are the major professional APCs of the immune system; however, their MHC-II-associated peptide repertoires have been hard to analyze, mostly because of their scarce presence in blood and tissues. In ...
    • Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands ... 
      Aravena, Octavio; Pesce Reyes, Bárbara; Soto, Lilian; Orrego, Natalia; Sabugo, Francisca; Wurmann, Pamela; Molina, María Carmen; Alfaro, Jorge; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (2011)
      The aim of this work was to study the effect of anti-TNF treatment on CD4+ Th1, Th17 and regulatory T cells (Tregs), together with CD8+ T cells and NK cells from rheumatoid arthritis (RA) patients. For this purpose, 18 RA ...
    • Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic ... 
      Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Hager Ribeiro, Carolina; Molina, María C.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
    • Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients 
      Cuchacovich Turteltaub, Miguel; Bueno, Daniel; Carvajal Gavilán, Rodrigo; Bravo, Nicolás; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego; Soto Sáez, Lilian (International League of Associations for Rheumatology (ILAR), 2014)
      Tumor necrosis factor (TNF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). This finding has led to the development of TNF blockers for RA treatment. However, response to these therapies is ...
    • Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells ... 
      García González, Paulina; Schinnerling, Katina; Sepúlveda Gutierrez, Alejandro; Maggi, Jaxaira; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce Reyes, Bárbara; Larrondo Lillo, Milton; Aravena, Octavio; Molina Sampayo, María Carmen; Catalán Martina, Diego; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media SA, 2017)
      There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a ...
    • Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic ... 
      Maggi, Jaxaira; Schinnerling, Katina; Pesce Reyes, Bárbara; Hilkens, Catharien M.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016)
      Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A (MPLA)-activated DCs [MPLA-tolerogenic DCs ...
    • Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients ... 
      García González, P. A.; Schinnerling, Katina; Sepúlveda A., Jocelyne; Ubilla Olguín, Gabriela; Soto, L.; Neira Quiroga, Oscar; Medhi, A. M.; Nel, H. J.; Catalán Martina, Diego; Thomas, R. C.; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (2016)
    • Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term ... 
      Peña, Corina; Gárate, David; Contreras Levicoy, Juan; Aravena, Octavio; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen- (CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a ...
    • Editorial: Searching for immune tolerance Manipulating New Molecules and Exploiting New Concepts on lymphocyte ... 
      Catalán Martina, Diego; Pino Lagos, Karina (Frontiers Media, 2016)
    • Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 ... 
      Pesce Reyes, Bárbara; Soto Sáez, Lilian; Sabugo Siraqyan, María Francisca; Wurmann Kiblisky, Pamela; Cuchacovich Turteltaub, Miguel; López Nitsche, Mercedes; Sotelo, P. H.; Molina Sampayo, María Carmen; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (2013)
      A new paradigm has emerged relating the pathogenesis of rheumatoid arthritis (RA), focused on the balance between T helper type 17 cells and regulatory T cells (Tregs). In humans, both subpopulations depend on ...
    • The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated ... 
      Durán Aniotz, Claudia; Segal, Gabriela; Salazar, Lorena; Pereda, Cristián; Falcón, Cristián; Tempio, Fabián; Aguilera, Raquel; González González, Rodrigo; Pérez Núñez, Claudio; Tittarelli, Andrés; Catalán Martina, Diego; Nervi, Bruno; Larrondo Lillo, Milton; Salazar Onfray, Flavio; López Nitsche, Mercedes (Springer, 2013)
      Introduction Immunization with autologous dendritic cells (DCs) loaded with a heat shock-conditioned allogeneic melanoma cell lysate caused lysate-specific delayed type hypersensitivity (DTH) reactions in a number ...
    • Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis 
      González, Carlos; Abello, Paula; Cepeda, Raquel; Salazar, Lorena; Aravena, Octavio; Pesce Reyes, Bárbara; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2007)
      Using the murine model of type II collagen-induced arthritis (CIA), we studied its evolution over time by histopathological, immunohistochemical and clinical evaluations. The first clinical symptoms appeared 28 days ...
    • Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in ... 
      Rosser, Elizabeth C.; Piper, Christopher J. M.; Matei, Diana E.; Blair, Paul A.; Rendeiro, André F.; Orford, Michael; Alber, Dagmar G.; Krausgruber, Thomas; Catalán Martina, Diego; Klein, Nigel; Manson, Jessica J.; Drozdov, Ignat; Bock, Christoph; Wedderburn, Lucy R.; Eaton, Simon; Mauri, Claudia (Cell Press, 2020)
      The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance of tolerance. However, whether microbiota-derived metabolites can modulate Breg ...
    • Neuropilin-1 in transplantation tolerance 
      Campos Mora, Mauricio; Morales, Rodrigo A.; Gajardo, Tania; Catalán Martina, Diego; Pino Lagos, Karina (2013)
      In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that ...
    • Nuevas armas inmunológicas para la medicina del siglo XXI: Terapia biológica basada en el uso de anticuerpos ... 
      Aguillón Gutiérrez, Juan Carlos; Contreras L., Juan; Dotte G., Andrés; Cruzat C., Andrea; Catalán Martina, Diego; Salazar A., Lorena; Molina S., María Carmen; Guerrero P., Julia; López Nitsche, Mercedes; Soto Sáez, Lilian; Salazar Onfray, Flavio; Cuchacovich Turteltaub, Miguel (Sociedad Médica de Santiago, 2003)
      The fusion of a murine B cell and a myeloma cell generates a hybridoma that produces monoclonal antibody (mAb). These murine mAb induce the HAMA (human anti-mouse antibodies) response. Murine mAb have been modified by ...
    • A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that ... 
      García González, Paulina; Morales, Rodrigo; Hoyos, Lorena; Maggi, Jaxaira; Campos, Javier; Pesce Reyes, Bárbara; Gárate, David; Larrondo Lillo, Milton; González González, Rodrigo; Soto Sáez, Lilian; Ramos, Verónica; Tobar, Pía; Molina, María Carmen; Pino Lagos, Karina; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (BioMed Central, 2013)
      Background: Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging due to its implications for the design of protocols suitable for clinical applications, which means not only using safe products, ...
    • Short-term lipopolysaccharide stimulation induces differentiation of murine bone marrow-derived dendritic ... 
      Salazar, Lorena; Aravena, Octavio; Contreras Levicoy, Juan; Pesce Reyes, Bárbara; Catalán Martina, Diego; Zúñiga, Roberto; Iruretagoyena, Mirentxu; Kalergis, Alexis M.; Aguillón Gutiérrez, Juan Carlos (2007)
      Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...
    • Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid ... 
      Schinnerling, Katina; Soto, Lilian; García González, Paulina; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Elsevier, 2015)
      To date, the available options to treat autoimmune diseases such as rheumatoid arthritis (RA) include traditional corticoids and biological drugs, which are not exempt of adverse effects. The development of cellular ...
    • STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by ... 
      Garrido Tapia, Macarena; Hernández González, Carolina; Ascui, Gabriel; Kramm, Karina; Morales Huber, Claudia; Garatea, Valentina; Zúniga, Roberto; Bustamante Zamorano, Marco; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego; Ribeiro, Carolina Hager; Molina Sampayo, María Carmen (Elsevier, 2017)
      NKG2D is an activating receptor expressed on NK cells that binds to a variety of ligands, including MICA and MICB. These cell surface glycoproteins are overexpressed under cellular transformation, thus playing an important ...
    • Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation 
      Soto, Lilian; Ferrier, Ashley; Aravena Madariaga, Octavio; Fonseca, Elianet; Berendsen, Jorge; Biere, Andrea; Bueno, Daniel; Ramos, Verónica; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (Frontiers Media, 2015)
      The activation threshold of B cells is tightly regulated by an array of inhibitory and activator receptors in such a way that disturbances in their expression can lead to the appearance of autoimmunity. The aim of this ...