Now showing items 1-20 of 37

    • Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Herrera Videla, Emilio; Alegria, Rene; Farías, Marcelo; Díaz López, Farah; Hernandez, Cherie; Uauy Dagach-Imbarack, Ricardo; Regnault, Timothy; Casanello, Paola; Krause, Bernardo (WILEY-BLACKWEL, 2016)
      Intra-uterine growth restriction (IUGR) is associated with short and long-term metabolic and cardiovascular alterations. Mice and rats have been extensively used to study the effects of IUGR, but there are notable differences ...
    • Alegría Vera, René Augusto (Universidad de Chile, 2015)
      La restricción del crecimiento intrauterino (RCIU) es una causa importante de mortalidad y morbilidad perinatal. Una interacción compleja y dinámica del ambiente materno, la placenta y el feto está involucrado en asegurar ...
    • Herrera Videla, Emilio; Reyes, Roberto V.; Giussani, Dino A.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Ebensperger Darrouy, Germán; Casanello, Paola; Méndez, Natalia; Ebensperger, Renato; Sepúlveda Kattan, Esteban; Pulgar, Víctor M.; Cabello, Gertrudis; Blanco, Carlos E.; Hanson, Mark A.; Parer, Julian T.; Llanos Mansilla, Jorge (European Society of Cardiology, 2008)
      Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal sheep (Ovis aries) and ...
    • Beñaldo Fuentes, Felipe; Araya Quijada, Claudio; Serón Ferre, María; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge (Wiley, 2020)
    • Herrera Videla, Emilio; González Candia, Alejandro (Elsevier, 2020)
    • Massardo Vega, Lucía; Lavados, H.; Jaimovich, Rodrigo; Herrera Videla, Emilio; Quevedo, L.; Alfaro, L.; Assef, V.; Coll, C.; Velásquez, C.; Pereira, M. E.; Olea, E.; Quintana, Juan Carlos (Elsevier Science, 2008-03)
      Introducción y objetivos. La interpretación de la tomografía de emisión de fotón único (SPECT) de perfusión miocárdica requiere conocer la reproducibilidad de la técnica. El objetivo fue analizar la correlación ...
    • Casanello, Paola; Herrera Videla, Emilio; Krause, Bernardo J. (INTECH, 2017)
      Most of the worldwide deaths in patients with non-communicable diseases are due to cardiovascular and metabolic diseases, which are determined by a mix of environmental, genetic and epigenetic factors, and by their ...
    • Torres Farfán, Claudia; Valenzuela, Francisco J.; Mondaca, Mauricio; Valenzuela, Guillermo J.; Krause, Bernardo; Herrera Videla, Emilio; Riquelme González, Raquel; Llanos Mansilla, Jorge; Serón Ferré, María (BLACKWELL PUBLISHING, 2008-08-15)
      Although the fetal pineal gland does not secrete melatonin, the fetus is exposed to melatonin of maternal origin. In the non-human primate fetus, melatonin acts as a trophic hormone for the adrenal gland, stimulating ...
    • Ebensperger Darrouy, Germán; Ebensperger, Renato; Herrera Videla, Emilio; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Lesage, Florian; Marengo, Juan José; Tejo, Rodrigo; Llanos Mansilla, Jorge; Reyes, Roberto (BLACKWELL PUBLISHING, 2005-09-15)
      In this study we looked for additional evidence to support the hypothesis that fetal llama reacts to hypoxaemia with adaptive brain hypometabolism. We determined fetal llama brain temperature, Na+ and K+ channel density ...
    • Herrera Videla, Emilio; Pulgar, Víctor M.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Reyes, Roberto V.; Ebensperger Darrouy, Germán; Parer, Julian T.; Valdéz, Enrique A.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A.; Llanos Mansilla, Jorge (AMER PHYSIOLOGICAL SOC, 2007-06)
      Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze consequences of ...
    • Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Aguilar, Miguel; González Candia, Alejandro; Rodríguez Borges, Jorge; Carrasco Pozo, Catalina; Canas, Daniel; García Herrera, Claudio; Herrera Videla, Emilio; Castillo Peñaloza, Rodrigo (MDPI, 2018)
      More than 140 million people live and works (in a chronic or intermittent form) above 2500 m worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 55,000 persons work in high ...
    • Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)
      Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
    • Herrera Videla, Emilio; Macchiavello, Roberto; Montt, Camilo; Ebensperger Darrouy, Germán; Díaz Navarrete, Marcela; Ramírez, Santiago; Parer, Julian T.; Serrón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge (John Wiley & Sons Ltd,, 2014)
      Chronic hypoxia during gestation and delivery results in oxidative stress and cerebrovascular dysfunction in the neonate. We assessed whether melatonin, a potent antioxidant and potential vasodilator, improves the cerebral ...
    • Thakor, Avnesh S.; Allison, Beth J.; Niu, Youguo; Botting, Kimberley J.; Serón Ferré, María; Herrera Videla, Emilio; Giussani, Dino A. (Wiley & Sons, 2015)
      Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the ...
    • Torres, Flavio; González Candia, Alejandro; Montt, Camilo; Ebensperger Darrouy, Germán; Chubretovic, Magdalena; Serón Ferré, María; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Wiley, 2015)
      Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health ...
    • Herrera Videla, Emilio; Farías, Jorge; González Candia, Alejandro; Short, Stefania; Carrasco Pozo, Catalina; Castillo Peñaloza, Rodrigo (MDPI, 2015)
      Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing ...
    • Reyes Catalán, Víctor; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Sanhueza Reinoso, Emilia; Giussani, D. A.; Llanos Mansilla, Jorge (American Physiological Society, 2020)
      Most mammals have a poor tolerance to hypoxia, and prolonged O-2 restriction can lead to organ injury, particularly during fetal and early postnatal life. Nevertheless, the llama (Lama Glama) has evolved efficient mechanisms ...