Now showing items 1-9 of 9

    • Domenech Lira, Raúl; Macho Fisher, Pilar (2008)
      Aging produces its own cardiovascular changes, mainly remodelling of arteries, heart and the microcirculation. These progressive changes, detected since adolescence, represent a major risk factor for the development of ...
    • Pescio, Sergio; Macho Fisher, Pilar; Penna Varela, Mario; Domenech Lira, Raúl (Oxford University Press, 1983)
      Summary: We studied the effects of ethanol on total coronary resistance and on the resistance across the left ventricular wall in the isolated empty beating heart of the dog. The coronaries were perfused with homologous ...
    • Domenech Lira, Raúl; Macho Fisher, Pilar; Barros, Felipe (Oxford University Press, 1990)
      Study objective - The aim was to test the hypothesis of a vascular waterfall in the epicardial veins due to compression by the left ventricular (LV) pressure. If this were so, the epicardial venous pressure should be a ...
    • Domenech Lira, Raúl; Sánchez, Gina; Donoso Laurent, Paulina; Parra Morales, Víctor; Macho Fisher, Pilar (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003-12)
      We have previously demonstrated that brief episodes of tachycardia prior to a prolonged occlusion of a coronary artery, followed by reperfusion, substantially reduce the infarct size. Adenosine receptors and mitochondrial ...
    • Domenech, Cristina; Macho Fisher, Pilar (1991)
      In the last few years, so many different substances produced by the endothelium have been discovered that this structure is considered today a paracrine organ. Among these substances, there are at least three with marked ...
    • Domenech Lira, Raúl; Macho Fisher, Pilar (SOC MEDICA SANTIAGO, 2008-12)
      Aging produces its own cardiovascular changes, mainly remodelling of arteries, heart and the microcirculation. These progressive changes, detected since adolescence, represent a major risk factor for the development of ...
    • Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      © 2014 Wolters Kluwer Health, Inc. All rights reserved.We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate ...
    • Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      © 2014 Wolters Kluwer Health, Inc. All rights reserved.We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate ...
    • Parra, Víctor M.; Macho Fisher, Pilar; Domenech Lira, Raúl (2010)
      We previously showed that exercise induces myocardial preconditioning in dogs and that early preconditioning is mediated through mitochondrial adenosine triphosphate-sensitive potassium channels. We decided to study if ...