Browsing by Author "XX676891"
Now showing items 1-20 of 67
-
(2007)A great body of experimental evidence collected over many years indicates that calcium has a central role in a variety of neuronal functions. In particular, calcium participates in synaptic plasticity, a neuronal process ...
-
(2012)In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl) propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg 2+) in HEPES buffer under physiological ...
-
(2009)Insertional mutations in exon 4 of the ferritin light chain (FTL) gene are associated with hereditary ferritinopathy (HF) or neuroferritinopathy, an autosomal dominant neurodegenerative disease characterized by progressive ...
-
(2002)Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
-
(2006)Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
-
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-06-01)Hereditary hemochromatosis (HH) is a condition in which intestinal iron absorption is greatly elevated. Present treatment is weekly phlebotomy, affecting quality of life and leading to recurrent infections. The iron ...
-
(2006)Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
-
(SPRINGER, 2005-10-03)Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
-
(1997)Previous studies have demonstrated that diferric transferrin and apotransferrin compete for the binding to basolateral transfertin receptors and that transferrin-mediated iron uptake by Caco-2 cells is inhibited by ...
-
(2008)Iron deficiency, a condition currently affecting similar to 3 billion people, persists in the 21st century despite half a millennium of medical treatment. Soybean ferritin (SBFn), a large, stable protein nanocage around a ...
-
(Journal of Nutrition, 2008-05)Iron deficiency, a condition currently affecting ;3 billion people, persists in the 21st century despite half a millennium of medical treatment. Soybean ferritin (SBFn), a large, stable protein nanocage around a mineral ...
-
(2007)Calcium and iron play dual roles in neuronal function: they are both essential but when present in excess they cause neuronal damage and may even induce neuronal death. Calcium signals are required for synaptic plasticity, ...
-
(Elsevier, 2017)Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises as to whether ...
-
(Elsevier B.V., 2017)© 2017 Elsevier B.V. Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises ...
-
(2006)There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich’s ataxia and Parkinson’s disease. ...
-
(Universidad de Chile, 2011)La biotecnología ha adquirido un rol fundamental en la industria de producción de biofármacos, la cual ofrece nuevas alternativas para el tratamiento de diversas enfermedades. Entre los más utilizados están los anticuerpos ...
-
(2012)The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5- dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu +2, ...
-
(Universidad de Chile, 2015)El hierro es un metal traza, fundamental para la existencia de la vida. Los niveles de hierro en el organismo deben ser altamente controlados ya que pequeñas variaciones desencadenan numerosas enfermedades, entre ellas la ...
-
(Wiley-Blackwell, 2016)The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physiological ROS production modulates redox-sensitive ...
